Hypoxic pulmonary vasoconstriction in cardiothoracic surgery: Basic mechanisms to potential therapies

Ben M. Tsai, Meijing Wang, Mark W. Turrentine, Yousuf Mahomed, John W. Brown, Daniel R. Meldrum

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Hypoxic pulmonary vasoconstriction is postulated to be an adaptive mechanism to match lung perfusion with ventilation; however, the consequences of the maladaptive effects of pulmonary vasoconstriction represent formidable therapeutic challenges. Understanding the basic mechanisms of hypoxic pulmonary vasoconstriction will enhance the assimilation of translational research into clinical practice. The purposes of this review are to (1) define basic mechanisms of pulmonary vasoconstriction and vasorelaxation; (2) delineate the biphasic contractile response to hypoxia; (3) critically examine data that support the mediator hypothesis versus the ion channel hypothesis; and (4) explore potential mechanistic-based therapies for hypoxic pulmonary vasoconstriction.

Original languageEnglish (US)
Pages (from-to)360-368
Number of pages9
JournalAnnals of Thoracic Surgery
Volume78
Issue number1
DOIs
StatePublished - Jul 1 2004

Fingerprint

Vasoconstriction
Lung
Therapeutics
Translational Medical Research
Ion Channels
Vasodilation
Ventilation
Perfusion

Keywords

  • 9

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Hypoxic pulmonary vasoconstriction in cardiothoracic surgery : Basic mechanisms to potential therapies. / Tsai, Ben M.; Wang, Meijing; Turrentine, Mark W.; Mahomed, Yousuf; Brown, John W.; Meldrum, Daniel R.

In: Annals of Thoracic Surgery, Vol. 78, No. 1, 01.07.2004, p. 360-368.

Research output: Contribution to journalReview article

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