Identical orocecal transit time and serum motilin in hyperthermia and normothermia

Alon Harris, William F. Keeling, Bruce J. Martin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Fever, exercise, and exposure to a hot environment can all cause symptoms of gastrointestinal dysfunction as they elevate body temperature. Nonetheless, the link between hyperthermia per se and these symptoms is unknown. To test the functional significance of increased body temperature, we investigated the influence of substantial passive hyperthermia on orocecal transit in 12 young, healthy men. Transit time was determined by a consistent rise in H2 concentration in a rebreathing apparatus after oral ingestion of 0.7 g lactulose/kg body weight. Lactulose was given in combination with a 350-ml liquid meal (360 kcal). After raising core temperature in warm water to 38.3° C, orocecal transit time was identical to control (90±13 min at 38.3° C, 92±13 min at 37.1° C). While hyperthermia did elevate heart rate and minute ventilation, serum motilin, gastrin, and cortisol were similar in the two conditions. The failure of a passive core temperature rise to alter mouth-to-cecum transit suggests that this aspect of alimentary function is independent of body temperature.

Original languageEnglish
Pages (from-to)1281-1284
Number of pages4
JournalDigestive Diseases and Sciences
Volume35
Issue number10
DOIs
StatePublished - Oct 1990

Fingerprint

Motilin
Fever
Body Temperature
Lactulose
Serum
Temperature
Cecum
Gastrins
Ventilation
Meals
Mouth
Hydrocortisone
Eating
Heart Rate
Body Weight
Exercise
Water

Keywords

  • cortisol
  • exertion
  • fever
  • gastrin
  • gastrointestinal tract

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Identical orocecal transit time and serum motilin in hyperthermia and normothermia. / Harris, Alon; Keeling, William F.; Martin, Bruce J.

In: Digestive Diseases and Sciences, Vol. 35, No. 10, 10.1990, p. 1281-1284.

Research output: Contribution to journalArticle

Harris, Alon ; Keeling, William F. ; Martin, Bruce J. / Identical orocecal transit time and serum motilin in hyperthermia and normothermia. In: Digestive Diseases and Sciences. 1990 ; Vol. 35, No. 10. pp. 1281-1284.
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