Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4.

Shelley M. Moore, Tiebing Liang, Tamara J. Graves, Kevin M. McCall, Lucinda G. Carr, Cindy L. Ehlers

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 ( ALDH1A1 ) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDH1A1 allele, ALDH1A1*4 , was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of the allele, and to see if it is associated with risk of alcoholism.

Original languageEnglish (US)
Pages (from-to)304-307
Number of pages4
JournalHuman genomics
Volume3
Issue number4
DOIs
StatePublished - Jul 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery

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    Moore, S. M., Liang, T., Graves, T. J., McCall, K. M., Carr, L. G., & Ehlers, C. L. (2009). Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4. Human genomics, 3(4), 304-307. https://doi.org/10.1186/1479-7364-3-4-304