Identification of a novel truncated αIIb integrin

Mohit Trikha, Yinlong Cai, David Grignon, Kenneth V. Honn

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Integrin αIIbβ3 requires its cytoplasmic tails to participate in tumor cell adhesion, spreading, and migration. Using 3' rapid amplification of cDNA ends, we have amplified two αIIb cDNAs from human leukemia, prostate adenocarcinoma, and melanoma cells. One of these is the predicted wild-type αIIb cDNA, and the other is a novel truncated αIIb variant. This variant is unique in that it lacks the transmembrane and cytoplasmic portions of the αIIb light chain. The truncated αIIb integrin protein is expressed by human leukemia, prostate adenocarcinoma, and melanoma cells but not by platelets or normal prostate epithelial or normal breast epithelial cells. Tumor cells secrete this protein and deposit it on the extracellular matrix. To our knowledge, this is the first report of a naturally occurring variant of an α integrin that lacks the transmembrane and cytoplasmic tail.

Original languageEnglish (US)
Pages (from-to)4771-4775
Number of pages5
JournalCancer Research
Volume58
Issue number21
StatePublished - Nov 1 1998

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Trikha, M., Cai, Y., Grignon, D., & Honn, K. V. (1998). Identification of a novel truncated αIIb integrin. Cancer Research, 58(21), 4771-4775.