Integrin αIIbβ3 requires its cytoplasmic tails to participate in tumor cell adhesion, spreading, and migration. Using 3' rapid amplification of cDNA ends, we have amplified two αIIb cDNAs from human leukemia, prostate adenocarcinoma, and melanoma cells. One of these is the predicted wild-type αIIb cDNA, and the other is a novel truncated αIIb variant. This variant is unique in that it lacks the transmembrane and cytoplasmic portions of the αIIb light chain. The truncated αIIb integrin protein is expressed by human leukemia, prostate adenocarcinoma, and melanoma cells but not by platelets or normal prostate epithelial or normal breast epithelial cells. Tumor cells secrete this protein and deposit it on the extracellular matrix. To our knowledge, this is the first report of a naturally occurring variant of an α integrin that lacks the transmembrane and cytoplasmic tail.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Nov 1 1998|
ASJC Scopus subject areas
- Cancer Research