Identification of a peptoid inhibitor of the proteasome 19S regulatory particle

Hyun Suk Lim, Chase T. Archer, Thomas Kodadek

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

The first chemical inhibitor of the 19S regulatory particle (RP) of the proteasome is described. The molecule was identified by screening a library of nucleoside-capped peptoids for binding to the yeast 26S proteasome in a crude extract. The hit was resynthesized and shown to block 19S RP-mediated protein unfolding in vitro and proteasome-mediated turnover of p27 in HeLa cells.

Original languageEnglish (US)
Pages (from-to)7750-7751
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number25
DOIs
StatePublished - Jun 27 2007
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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