Identification of a potential ejaculation generator in the spinal cord

William Truitt, Lique M. Coolen

Research output: Contribution to journalArticle

251 Citations (Scopus)

Abstract

We tested the significance of a population of lumbar spinothalamic cells for male sexual behavior in rats. These cells are positioned to relay ejaculation-related signals from reproductive organs to the brain, and they express neurokinin-1 receptors. Ablation of these neurons by the selective toxin SSP- saporin resulted in a complete disruption of ejaculatory behavior. In contrast, other components of sexual behavior remained intact. These results suggest that this population of spinothalamic cells plays a pivotal role in generation of ejaculatory behavior and may be part of a spinal ejaculation generator.

Original languageEnglish (US)
Pages (from-to)1566-1569
Number of pages4
JournalScience
Volume297
Issue number5586
DOIs
StatePublished - Aug 30 2002
Externally publishedYes

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Ejaculation
Spinal Cord
Sexual Behavior
Neurokinin-1 Receptors
Population
Neurons
Brain

ASJC Scopus subject areas

  • General

Cite this

Identification of a potential ejaculation generator in the spinal cord. / Truitt, William; Coolen, Lique M.

In: Science, Vol. 297, No. 5586, 30.08.2002, p. 1566-1569.

Research output: Contribution to journalArticle

Truitt, William ; Coolen, Lique M. / Identification of a potential ejaculation generator in the spinal cord. In: Science. 2002 ; Vol. 297, No. 5586. pp. 1566-1569.
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