Identification of a potential ejaculation generator in the spinal cord

William A. Truitt, Lique M. Coolen

Research output: Contribution to journalArticlepeer-review

260 Scopus citations


We tested the significance of a population of lumbar spinothalamic cells for male sexual behavior in rats. These cells are positioned to relay ejaculation-related signals from reproductive organs to the brain, and they express neurokinin-1 receptors. Ablation of these neurons by the selective toxin SSP- saporin resulted in a complete disruption of ejaculatory behavior. In contrast, other components of sexual behavior remained intact. These results suggest that this population of spinothalamic cells plays a pivotal role in generation of ejaculatory behavior and may be part of a spinal ejaculation generator.

Original languageEnglish (US)
Pages (from-to)1566-1569
Number of pages4
Issue number5586
StatePublished - Aug 30 2002
Externally publishedYes

ASJC Scopus subject areas

  • General

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