Identification of cartilage matrix glycoprotein in synovial fluid in human osteoarthritis

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cartilage matrix glycoprotein (CMGP) is a high molecular weight protein found in hyaline cartilage and fibrocartilage. It consits of disulfide-bonded subunits, each with an apparent molecular weight of 116,000. Fragmentation of CMGP is noted in extracts of osteoarthritic canine cartilage. CMGP has been identified in the serum and synovial fluid of dogs with experimentally induced osteoarthritis. It has now been identified in synovial fluid from osteoarthritic human joints, but not in synovial fluid from joints of patients with other arthritides or joint abnormalities. The possible significance of CMGP in synovial fluid in human osteoarthritis is discussed.

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalArthritis & Rheumatism
Volume31
Issue number4
DOIs
StatePublished - Apr 1988

Fingerprint

Matrilin Proteins
Synovial Fluid
Osteoarthritis
Joints
Molecular Weight
Fibrocartilage
Hyaline Cartilage
Disulfides
Arthritis
Cartilage
Canidae
Dogs
Serum
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Identification of cartilage matrix glycoprotein in synovial fluid in human osteoarthritis. / Fife, Rose S.

In: Arthritis & Rheumatism, Vol. 31, No. 4, 04.1988, p. 553-556.

Research output: Contribution to journalArticle

@article{ff4436b260fc4f86b5f1afbb3dbbeb24,
title = "Identification of cartilage matrix glycoprotein in synovial fluid in human osteoarthritis",
abstract = "Cartilage matrix glycoprotein (CMGP) is a high molecular weight protein found in hyaline cartilage and fibrocartilage. It consits of disulfide-bonded subunits, each with an apparent molecular weight of 116,000. Fragmentation of CMGP is noted in extracts of osteoarthritic canine cartilage. CMGP has been identified in the serum and synovial fluid of dogs with experimentally induced osteoarthritis. It has now been identified in synovial fluid from osteoarthritic human joints, but not in synovial fluid from joints of patients with other arthritides or joint abnormalities. The possible significance of CMGP in synovial fluid in human osteoarthritis is discussed.",
author = "Fife, {Rose S.}",
year = "1988",
month = "4",
doi = "10.1002/art.1780310414",
language = "English (US)",
volume = "31",
pages = "553--556",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

TY - JOUR

T1 - Identification of cartilage matrix glycoprotein in synovial fluid in human osteoarthritis

AU - Fife, Rose S.

PY - 1988/4

Y1 - 1988/4

N2 - Cartilage matrix glycoprotein (CMGP) is a high molecular weight protein found in hyaline cartilage and fibrocartilage. It consits of disulfide-bonded subunits, each with an apparent molecular weight of 116,000. Fragmentation of CMGP is noted in extracts of osteoarthritic canine cartilage. CMGP has been identified in the serum and synovial fluid of dogs with experimentally induced osteoarthritis. It has now been identified in synovial fluid from osteoarthritic human joints, but not in synovial fluid from joints of patients with other arthritides or joint abnormalities. The possible significance of CMGP in synovial fluid in human osteoarthritis is discussed.

AB - Cartilage matrix glycoprotein (CMGP) is a high molecular weight protein found in hyaline cartilage and fibrocartilage. It consits of disulfide-bonded subunits, each with an apparent molecular weight of 116,000. Fragmentation of CMGP is noted in extracts of osteoarthritic canine cartilage. CMGP has been identified in the serum and synovial fluid of dogs with experimentally induced osteoarthritis. It has now been identified in synovial fluid from osteoarthritic human joints, but not in synovial fluid from joints of patients with other arthritides or joint abnormalities. The possible significance of CMGP in synovial fluid in human osteoarthritis is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0023923478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023923478&partnerID=8YFLogxK

U2 - 10.1002/art.1780310414

DO - 10.1002/art.1780310414

M3 - Article

C2 - 3358813

AN - SCOPUS:0023923478

VL - 31

SP - 553

EP - 556

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 4

ER -