Identification of cartilage matrix glycoprotein in synovial fluid in human osteoarthritis

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Cartilage matrix glycoprotein (CMGP) is a high molecular weight protein found in hyaline cartilage and fibrocartilage. It consits of disulfide-bonded subunits, each with an apparent molecular weight of 116,000. Fragmentation of CMGP is noted in extracts of osteoarthritic canine cartilage. CMGP has been identified in the serum and synovial fluid of dogs with experimentally induced osteoarthritis. It has now been identified in synovial fluid from osteoarthritic human joints, but not in synovial fluid from joints of patients with other arthritides or joint abnormalities. The possible significance of CMGP in synovial fluid in human osteoarthritis is discussed.

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalArthritis & Rheumatism
Volume31
Issue number4
DOIs
StatePublished - Apr 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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