Identification of cartilage matrix glycoprotein in synovial fluid in human osteoarthritis

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17 Citations (Scopus)

Abstract

Cartilage matrix glycoprotein (CMGP) is a high molecular weight protein found in hyaline cartilage and fibrocartilage. It consits of disulfide-bonded subunits, each with an apparent molecular weight of 116,000. Fragmentation of CMGP is noted in extracts of osteoarthritic canine cartilage. CMGP has been identified in the serum and synovial fluid of dogs with experimentally induced osteoarthritis. It has now been identified in synovial fluid from osteoarthritic human joints, but not in synovial fluid from joints of patients with other arthritides or joint abnormalities. The possible significance of CMGP in synovial fluid in human osteoarthritis is discussed.

Original languageEnglish
Pages (from-to)553-556
Number of pages4
JournalArthritis and Rheumatism
Volume31
Issue number4
StatePublished - 1988

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Matrilin Proteins
Synovial Fluid
Osteoarthritis
Joints
Molecular Weight
Fibrocartilage
Hyaline Cartilage
Disulfides
Arthritis
Cartilage
Canidae
Dogs
Serum
Proteins

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Identification of cartilage matrix glycoprotein in synovial fluid in human osteoarthritis. / Fife, Rose.

In: Arthritis and Rheumatism, Vol. 31, No. 4, 1988, p. 553-556.

Research output: Contribution to journalArticle

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