Identification of CD56 and CD57 by flow cytometry in Ewing's sarcoma or primitive neuroactodermal tumor

L. J. Gardner, J. M. Polski, Robert Fallon, C. H. Dunphy

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

CD56 and CD57 are commonly considered as natural killer and neuroectodermal markers, but their expression has been identified in a wide spectrum of neoplasms including some cases of Ewing's sarcoma (ES) and primitive neuroectodermal turner (PNET). We report two cases of small, round blue cell tumor (SRBCT), in which flow cytometry immunophenotyping (FCI) detected strong expression of CD56 and CD57 (one case). Immunohistochemical staining with Leu-19 and Leu-7 con firmed the FI results. Although CD56 and CD57 expression is consistent with ES/PNET, it can be potentially misleading if results of FCI are interpreted in the absence of other findings. These cases suggest the utility of FCI in undifferentiatedd SRBCT. The literature on CD56 and CD57 expression in ES/PNET is reviewed and discussed.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalVirchows Archiv
Volume433
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

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Immunophenotyping
Ewing's Sarcoma
Flow Cytometry
Neoplasms
Staining and Labeling

Keywords

  • Antigens
  • Ewing's sarcoma
  • Flow cytometry
  • Immunophenotyping
  • NCAM
  • Primitive neuroectodermal tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Identification of CD56 and CD57 by flow cytometry in Ewing's sarcoma or primitive neuroactodermal tumor. / Gardner, L. J.; Polski, J. M.; Fallon, Robert; Dunphy, C. H.

In: Virchows Archiv, Vol. 433, No. 1, 1998, p. 35-40.

Research output: Contribution to journalArticle

Gardner, L. J. ; Polski, J. M. ; Fallon, Robert ; Dunphy, C. H. / Identification of CD56 and CD57 by flow cytometry in Ewing's sarcoma or primitive neuroactodermal tumor. In: Virchows Archiv. 1998 ; Vol. 433, No. 1. pp. 35-40.
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