Identification of central venous hemodialysis catheter-related infection by a semiquantitative culture method

Hans Peter Brodersen, Benno Beckers, Matthias Clauss, Jürgen vom Dahl, Jürgen Floege, Ulf Janssen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Central venous hemodialysis catheter-related infection is major cause of morbidity and mortality in the hemodialysis (HD) population. Due to an impaired immune response, symptoms and signs of infection may not be obvious, and thus bacteremia is often diagnosed and treated protractedly. In contrast, induction of the acute phase response is frequently observed in HD patients even without infection. Moreover, positive catheter cultures may result from contamination, asymptomatic colonization or infection. The aim of the present study was to compare the number of colonies from HD catheter tips, with symptoms and signs of infection in HD patients. Methods: In a 10-year, single-center study, 53 HD patients (29 men, 24 women; mean age 66 ± 10 years) who had their dialysis catheters removed were divided into 3 groups according to the number of colonies grovdng after rolling the catheter tip across blood agar (group I: 50 colonies [n=16]). Results: The maximum white blood cell (WBC) count did not differ significantly between patients with low- and high-density colonization (group I: 11.746 ± 9.680 WBC/μL vs. group III: 13.479 ± 6.252 WBC/μL, p=NS) while maximum C-reactive protein (CRP) levels were higher in patients with high-density colonization (group I: 8.6 ± 6.8 vs. group III: 19.2 ± 12.2 mg/dL, p

Original languageEnglish (US)
Pages (from-to)462-467
Number of pages6
JournalJournal of Nephrology
Volume20
Issue number4
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

Catheter-Related Infections
Central Venous Catheters
Renal Dialysis
Catheters
Infection
Signs and Symptoms
Leukocytes
Acute-Phase Reaction
Blood Group Antigens
Bacteremia
Leukocyte Count
C-Reactive Protein
Agar
Dialysis
Morbidity
Mortality
Population

Keywords

  • Bacteremia
  • C-reactive protein
  • Hemodialysis catheter
  • Infection

ASJC Scopus subject areas

  • Nephrology

Cite this

Brodersen, H. P., Beckers, B., Clauss, M., vom Dahl, J., Floege, J., & Janssen, U. (2007). Identification of central venous hemodialysis catheter-related infection by a semiquantitative culture method. Journal of Nephrology, 20(4), 462-467.

Identification of central venous hemodialysis catheter-related infection by a semiquantitative culture method. / Brodersen, Hans Peter; Beckers, Benno; Clauss, Matthias; vom Dahl, Jürgen; Floege, Jürgen; Janssen, Ulf.

In: Journal of Nephrology, Vol. 20, No. 4, 07.2007, p. 462-467.

Research output: Contribution to journalArticle

Brodersen, HP, Beckers, B, Clauss, M, vom Dahl, J, Floege, J & Janssen, U 2007, 'Identification of central venous hemodialysis catheter-related infection by a semiquantitative culture method', Journal of Nephrology, vol. 20, no. 4, pp. 462-467.
Brodersen, Hans Peter ; Beckers, Benno ; Clauss, Matthias ; vom Dahl, Jürgen ; Floege, Jürgen ; Janssen, Ulf. / Identification of central venous hemodialysis catheter-related infection by a semiquantitative culture method. In: Journal of Nephrology. 2007 ; Vol. 20, No. 4. pp. 462-467.
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