Identification of clinical stage A nonseminomatous testis cancer patients at extremely low risk for metastatic disease

A combined approach using quantitive immunohistochemical, histopathologic, and radiologic assessment

Ilan Leibovitch, Richard Foster, Kenyon K. Kopecky, Peter Albers, Thomas Ulbright, John P. Donohue

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Purpose: To evaluate previously determined predictors of metastasis in low-stage testis cancer in a consecutive group of clinical stage A patients. Patients and Methods: Ninety-one consecutive clinical stage A nonseminomatous germ cell tumor (NSGCT) patients who underwent primary nerve-sparing retroperitoneal lymph node dissection (NSRPLND) had orchiectomy specimens and computed tomographic (CT) scans evaluated blindly in a quantitative fashion. These scores were then correlated with pathologic stage using previously determined paradigms. Results: Using volume of embryonal carcinoma in the orchiectomy specimen, lymph node diameters in the primary landing zones and MIB-1 staining of the orchiectomy specimen, 41 patients were classified as low risk for metastasis. Forty of these 41 had pathologic stage A disease at RPLND. Conclusion: These parameters can identify a low-risk group patients for metastasis who can be rationally offered surveillance.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalJournal of Clinical Oncology
Volume16
Issue number1
StatePublished - Jan 1998

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Testicular Neoplasms
Orchiectomy
Neoplasm Metastasis
Embryonal Carcinoma
Lymph Node Excision
Lymph Nodes
Staining and Labeling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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abstract = "Purpose: To evaluate previously determined predictors of metastasis in low-stage testis cancer in a consecutive group of clinical stage A patients. Patients and Methods: Ninety-one consecutive clinical stage A nonseminomatous germ cell tumor (NSGCT) patients who underwent primary nerve-sparing retroperitoneal lymph node dissection (NSRPLND) had orchiectomy specimens and computed tomographic (CT) scans evaluated blindly in a quantitative fashion. These scores were then correlated with pathologic stage using previously determined paradigms. Results: Using volume of embryonal carcinoma in the orchiectomy specimen, lymph node diameters in the primary landing zones and MIB-1 staining of the orchiectomy specimen, 41 patients were classified as low risk for metastasis. Forty of these 41 had pathologic stage A disease at RPLND. Conclusion: These parameters can identify a low-risk group patients for metastasis who can be rationally offered surveillance.",
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T1 - Identification of clinical stage A nonseminomatous testis cancer patients at extremely low risk for metastatic disease

T2 - A combined approach using quantitive immunohistochemical, histopathologic, and radiologic assessment

AU - Leibovitch, Ilan

AU - Foster, Richard

AU - Kopecky, Kenyon K.

AU - Albers, Peter

AU - Ulbright, Thomas

AU - Donohue, John P.

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AB - Purpose: To evaluate previously determined predictors of metastasis in low-stage testis cancer in a consecutive group of clinical stage A patients. Patients and Methods: Ninety-one consecutive clinical stage A nonseminomatous germ cell tumor (NSGCT) patients who underwent primary nerve-sparing retroperitoneal lymph node dissection (NSRPLND) had orchiectomy specimens and computed tomographic (CT) scans evaluated blindly in a quantitative fashion. These scores were then correlated with pathologic stage using previously determined paradigms. Results: Using volume of embryonal carcinoma in the orchiectomy specimen, lymph node diameters in the primary landing zones and MIB-1 staining of the orchiectomy specimen, 41 patients were classified as low risk for metastasis. Forty of these 41 had pathologic stage A disease at RPLND. Conclusion: These parameters can identify a low-risk group patients for metastasis who can be rationally offered surveillance.

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