Identification of gene expression changes in transgenic C. elegans overexpressing human α-synuclein

Suvi Vartiainen, Petri Pehkonen, Merja Lakso, Richard Nass, Garry Wong

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

α-Synuclein containing cellular inclusions are a hallmark of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. A genome wide expression screen was performed in C. elegans overexpressing both wild-type and A53T human α-synuclein. 433 genes were up- and 67 genes down-regulated by statistical and fold change (> or

Original languageEnglish (US)
Pages (from-to)477-486
Number of pages10
JournalNeurobiology of Disease
Volume22
Issue number3
DOIs
StatePublished - Jun 2006
Externally publishedYes

Fingerprint

Synucleins
Multiple System Atrophy
Gene Expression
Lewy Body Disease
Inclusion Bodies
Genes
Parkinson Disease
Genome

Keywords

  • α-Synuclein
  • Bioinformatics
  • C. elegans
  • Clustering
  • Microarray
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology

Cite this

Identification of gene expression changes in transgenic C. elegans overexpressing human α-synuclein. / Vartiainen, Suvi; Pehkonen, Petri; Lakso, Merja; Nass, Richard; Wong, Garry.

In: Neurobiology of Disease, Vol. 22, No. 3, 06.2006, p. 477-486.

Research output: Contribution to journalArticle

Vartiainen, Suvi ; Pehkonen, Petri ; Lakso, Merja ; Nass, Richard ; Wong, Garry. / Identification of gene expression changes in transgenic C. elegans overexpressing human α-synuclein. In: Neurobiology of Disease. 2006 ; Vol. 22, No. 3. pp. 477-486.
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