Identification of hepatitis C viruses with a nonconserved sequence of the 5' untranslated region

Chao-Hung Lee, C. Cheng, J. Wang, L. Lumeng

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The nucleotide sequence of the 5' untranslated region of hepatitis C virus (HCV) has been shown to be conserved. In contrast, we have detected more sequence variation in this region in several HCV isolates than hitherto expected. The nucleotide sequences of the 5' untranslated regions of these isolates differ significantly from that of the prototype but are very similar to each other. We believe that these isolates belong to the same type of HCV. Among 240 HCV RNA polymerase chain reaction-positive specimens that we examined, 7 belong to this type. The results suggest that the HCV variants that we detected represent a different type of HCV and that they are responsible for approximately 3% of HCV infections in patients that we have examined.

Original languageEnglish
Pages (from-to)1602-1604
Number of pages3
JournalJournal of Clinical Microbiology
Volume30
Issue number6
StatePublished - 1992

Fingerprint

5' Untranslated Regions
Hepacivirus
Virus Diseases
DNA-Directed RNA Polymerases
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Identification of hepatitis C viruses with a nonconserved sequence of the 5' untranslated region. / Lee, Chao-Hung; Cheng, C.; Wang, J.; Lumeng, L.

In: Journal of Clinical Microbiology, Vol. 30, No. 6, 1992, p. 1602-1604.

Research output: Contribution to journalArticle

@article{d6645653e3d549d9944a01efa1946ad4,
title = "Identification of hepatitis C viruses with a nonconserved sequence of the 5' untranslated region",
abstract = "The nucleotide sequence of the 5' untranslated region of hepatitis C virus (HCV) has been shown to be conserved. In contrast, we have detected more sequence variation in this region in several HCV isolates than hitherto expected. The nucleotide sequences of the 5' untranslated regions of these isolates differ significantly from that of the prototype but are very similar to each other. We believe that these isolates belong to the same type of HCV. Among 240 HCV RNA polymerase chain reaction-positive specimens that we examined, 7 belong to this type. The results suggest that the HCV variants that we detected represent a different type of HCV and that they are responsible for approximately 3{\%} of HCV infections in patients that we have examined.",
author = "Chao-Hung Lee and C. Cheng and J. Wang and L. Lumeng",
year = "1992",
language = "English",
volume = "30",
pages = "1602--1604",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "6",

}

TY - JOUR

T1 - Identification of hepatitis C viruses with a nonconserved sequence of the 5' untranslated region

AU - Lee, Chao-Hung

AU - Cheng, C.

AU - Wang, J.

AU - Lumeng, L.

PY - 1992

Y1 - 1992

N2 - The nucleotide sequence of the 5' untranslated region of hepatitis C virus (HCV) has been shown to be conserved. In contrast, we have detected more sequence variation in this region in several HCV isolates than hitherto expected. The nucleotide sequences of the 5' untranslated regions of these isolates differ significantly from that of the prototype but are very similar to each other. We believe that these isolates belong to the same type of HCV. Among 240 HCV RNA polymerase chain reaction-positive specimens that we examined, 7 belong to this type. The results suggest that the HCV variants that we detected represent a different type of HCV and that they are responsible for approximately 3% of HCV infections in patients that we have examined.

AB - The nucleotide sequence of the 5' untranslated region of hepatitis C virus (HCV) has been shown to be conserved. In contrast, we have detected more sequence variation in this region in several HCV isolates than hitherto expected. The nucleotide sequences of the 5' untranslated regions of these isolates differ significantly from that of the prototype but are very similar to each other. We believe that these isolates belong to the same type of HCV. Among 240 HCV RNA polymerase chain reaction-positive specimens that we examined, 7 belong to this type. The results suggest that the HCV variants that we detected represent a different type of HCV and that they are responsible for approximately 3% of HCV infections in patients that we have examined.

UR - http://www.scopus.com/inward/record.url?scp=0026742307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026742307&partnerID=8YFLogxK

M3 - Article

VL - 30

SP - 1602

EP - 1604

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 6

ER -