Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14

Yan Xu, Graham Casey

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We describe the cloning of a novel G protein-coupled receptor, termed ovarian cancer G protein-coupled receptor 1 (OGR1), from an ovarian cancer cell line that maps to chromosome 14q31. The predicted open reading frame of OGR1 encodes a protein of 365 amino acids. OGR1 is expressed as a single 3.0- kb transcript in several tissues, including spleen, testis, small intestine, peripheral blood leukocytes, brain, heart, lung, placenta, and kidney, with no detectable OGR1 expression in thymus, prostate, ovary, colon, liver, skeletal muscle, or pancreas. OGR1 shares strongest homology (49-54%) with the human orphan receptor GPR4. The structural features of OGR1 suggest that the ligand for OGR1 is likely to be a small peptide or a small bioactive molecule.

Original languageEnglish (US)
Pages (from-to)397-402
Number of pages6
JournalGenomics
Volume35
Issue number2
DOIs
StatePublished - Jul 15 1996
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 14
Forensic Anthropology
G-Protein-Coupled Receptors
Ovarian Neoplasms
Thymus Gland
Placenta
Open Reading Frames
Small Intestine
Testis
Organism Cloning
Prostate
Pancreas
Ovary
Colon
Skeletal Muscle
Leukocytes
Spleen
Chromosomes
Ligands
Kidney

ASJC Scopus subject areas

  • Genetics

Cite this

Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14. / Xu, Yan; Casey, Graham.

In: Genomics, Vol. 35, No. 2, 15.07.1996, p. 397-402.

Research output: Contribution to journalArticle

@article{f86a849266ad4774898e99a7771011e6,
title = "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14",
abstract = "We describe the cloning of a novel G protein-coupled receptor, termed ovarian cancer G protein-coupled receptor 1 (OGR1), from an ovarian cancer cell line that maps to chromosome 14q31. The predicted open reading frame of OGR1 encodes a protein of 365 amino acids. OGR1 is expressed as a single 3.0- kb transcript in several tissues, including spleen, testis, small intestine, peripheral blood leukocytes, brain, heart, lung, placenta, and kidney, with no detectable OGR1 expression in thymus, prostate, ovary, colon, liver, skeletal muscle, or pancreas. OGR1 shares strongest homology (49-54{\%}) with the human orphan receptor GPR4. The structural features of OGR1 suggest that the ligand for OGR1 is likely to be a small peptide or a small bioactive molecule.",
author = "Yan Xu and Graham Casey",
year = "1996",
month = "7",
day = "15",
doi = "10.1006/geno.1996.0377",
language = "English (US)",
volume = "35",
pages = "397--402",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14

AU - Xu, Yan

AU - Casey, Graham

PY - 1996/7/15

Y1 - 1996/7/15

N2 - We describe the cloning of a novel G protein-coupled receptor, termed ovarian cancer G protein-coupled receptor 1 (OGR1), from an ovarian cancer cell line that maps to chromosome 14q31. The predicted open reading frame of OGR1 encodes a protein of 365 amino acids. OGR1 is expressed as a single 3.0- kb transcript in several tissues, including spleen, testis, small intestine, peripheral blood leukocytes, brain, heart, lung, placenta, and kidney, with no detectable OGR1 expression in thymus, prostate, ovary, colon, liver, skeletal muscle, or pancreas. OGR1 shares strongest homology (49-54%) with the human orphan receptor GPR4. The structural features of OGR1 suggest that the ligand for OGR1 is likely to be a small peptide or a small bioactive molecule.

AB - We describe the cloning of a novel G protein-coupled receptor, termed ovarian cancer G protein-coupled receptor 1 (OGR1), from an ovarian cancer cell line that maps to chromosome 14q31. The predicted open reading frame of OGR1 encodes a protein of 365 amino acids. OGR1 is expressed as a single 3.0- kb transcript in several tissues, including spleen, testis, small intestine, peripheral blood leukocytes, brain, heart, lung, placenta, and kidney, with no detectable OGR1 expression in thymus, prostate, ovary, colon, liver, skeletal muscle, or pancreas. OGR1 shares strongest homology (49-54%) with the human orphan receptor GPR4. The structural features of OGR1 suggest that the ligand for OGR1 is likely to be a small peptide or a small bioactive molecule.

UR - http://www.scopus.com/inward/record.url?scp=0030586244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030586244&partnerID=8YFLogxK

U2 - 10.1006/geno.1996.0377

DO - 10.1006/geno.1996.0377

M3 - Article

VL - 35

SP - 397

EP - 402

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 2

ER -