Identification of link proteins and a 116,000-Dalton matrix protein in canine meniscus

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13 Scopus citations


The menisci are collagen-rich, fibrocartilagenous structures which are important in protecting the articular cartilage of the knee from some of the impact of weightbearing. Meniscal proteoglycans have been studied in several mammalian species, including the dog, but very little is known about the noncollagenous proteins of the menisci. In the present study, 4 m guanidinium chloride extracts of meniscal cartilage from normal adult mongrel dogs were studied, and several noncollagenous proteins, including the link proteins and a 116,000-Da subunit protein, which we have recently described in articular cartilage, were found in meniscal cartilage. The 116,000-Da subunit protein represents 3.8% of the total protein extracted from meniscal cartilage. The link proteins sedimented in the bottom of an associative cesium chloride density gradient, where high-buoyant-density proteoglycans sediment.

Original languageEnglish (US)
Pages (from-to)682-688
Number of pages7
JournalArchives of Biochemistry and Biophysics
Issue number2
StatePublished - Aug 1 1985

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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