Identification of neural circuits underlying P300 abnormalities in schizophrenia

Brian F. O'Donnell, Robert W. McCarley, Geoffrey F. Potts, Dean F. Salisbury, Paul G. Nestor, Yoshio Hirayasu, Margaret A. Niznikiewicz, John Barnard, Zi Jen Shen, David M. Weinstein, Fred L. Bookstein, Martha E. Shenton

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Event-related potentials (ERPs) provide a noninvasive method to evaluate neural activation and cognitive processes in schizophrenia. The pathophysiological significance of these findings would be greatly enhanced if scalp-recorded ERP abnormalities could be related to specific neural circuits and/or regions of the brain. Using quantitative approaches in which scalp-recorded ERP components are correlated with underlying neuroanatomy in schizophrenia, we focused on biophysical and statistical procedures (partial least squares) to relate the auditory P300 component to anatomic measures obtained from quantitative magnetic resonance imaging. These findings are consistent with other evidence that temporal lobe structures contribute to the generation of the scalp-recorded P300 component and that P300 amplitude asymmetry over temporal recording sites on the scalp may reflect anatomic asymmetries in the volume of the superior temporal gyrus in schizophrenia.

Original languageEnglish (US)
Pages (from-to)388-398
Number of pages11
Issue number3
StatePublished - May 1999


  • Event-related potentials
  • MRI
  • Neuroanatomy
  • P300
  • Schizophrenia

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Psychology(all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology

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