Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Curtis R. Chong, David Z. Qian, Fan Pan, Yongfeng Wei, Roberto Pili, David J. Sullivan, Jun O. Liu

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

To rapidly discover clinically useful angiogenesis inhibitors, we created and screened a library of existing drugs for inhibition of endothelial cell proliferation. Mycophenolic acid (MPA), an immunosuppressive drug, was found to potently inhibit endothelial cell proliferation in vitro and block tumor-induced angiogenesis in vivo. Using RNA interference, we found that knockdown of one of the two known isoforms of inosine monophosphate dehydrogenase (IMPDH-1) is sufficient to cause endothelial cell cycle arrest.

Original languageEnglish (US)
Pages (from-to)2677-2680
Number of pages4
JournalJournal of Medicinal Chemistry
Volume49
Issue number9
DOIs
StatePublished - May 4 2006
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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