Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Curtis R. Chong, David Z. Qian, Fan Pan, Yongfeng Wei, Roberto Pili, David J. Sullivan, Jun O. Liu

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

To rapidly discover clinically useful angiogenesis inhibitors, we created and screened a library of existing drugs for inhibition of endothelial cell proliferation. Mycophenolic acid (MPA), an immunosuppressive drug, was found to potently inhibit endothelial cell proliferation in vitro and block tumor-induced angiogenesis in vivo. Using RNA interference, we found that knockdown of one of the two known isoforms of inosine monophosphate dehydrogenase (IMPDH-1) is sufficient to cause endothelial cell cycle arrest.

Original languageEnglish (US)
Pages (from-to)2677-2680
Number of pages4
JournalJournal of Medicinal Chemistry
Volume49
Issue number9
DOIs
StatePublished - May 4 2006
Externally publishedYes

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Inosine Monophosphate
Endothelial cells
Oxidoreductases
Endothelial Cells
Cell proliferation
Cell Proliferation
Pharmaceutical Preparations
Mycophenolic Acid
Angiogenesis Inhibitors
Immunosuppressive Agents
RNA Interference
Cell Cycle Checkpoints
Tumors
Protein Isoforms
RNA
Neoplasms

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. / Chong, Curtis R.; Qian, David Z.; Pan, Fan; Wei, Yongfeng; Pili, Roberto; Sullivan, David J.; Liu, Jun O.

In: Journal of Medicinal Chemistry, Vol. 49, No. 9, 04.05.2006, p. 2677-2680.

Research output: Contribution to journalArticle

Chong, Curtis R. ; Qian, David Z. ; Pan, Fan ; Wei, Yongfeng ; Pili, Roberto ; Sullivan, David J. ; Liu, Jun O. / Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. In: Journal of Medicinal Chemistry. 2006 ; Vol. 49, No. 9. pp. 2677-2680.
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