Identifying candidate genes for mania and psychosis using a convergent functional genomics approach

A. B. Niculescu, D. S. Segal, R. Kuczenski, T. Barrett, R. Hauger, J. R. Kelsoe

Research output: Contribution to journalArticle


We are using amphetamine treatments of rats as an animal model for mania and psychosis. Specific brain regions are analyzed comprehensively for changes in gene expression using oligonucleotide GeneChip microarrays. The data is then matched against human genomic loci associated with bipolar disorders and schizophrenia. Our results so far using this convergent approach have identified several candidate genes -signal transduction molecules, transcription factors that may be involved in the pathogenesis of mood disorders and psychosis.

Original languageEnglish (US)
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number4
StatePublished - Aug 7 2000


ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this