Identifying candidate genes for mania and psychosis using a convergent functional genomics approach

Alexander Niculescu, D. S. Segal, R. Kuczenski, T. Barrett, R. Hauger, J. R. Kelsoe

Research output: Contribution to journalArticle

Abstract

We are using amphetamine treatments of rats as an animal model for mania and psychosis. Specific brain regions are analyzed comprehensively for changes in gene expression using oligonucleotide GeneChip microarrays. The data is then matched against human genomic loci associated with bipolar disorders and schizophrenia. Our results so far using this convergent approach have identified several candidate genes -signal transduction molecules, transcription factors that may be involved in the pathogenesis of mood disorders and psychosis.

Original languageEnglish (US)
Pages (from-to)481
Number of pages1
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume96
Issue number4
StatePublished - Aug 7 2000
Externally publishedYes

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Genomics
Bipolar Disorder
Psychotic Disorders
Amphetamine
Oligonucleotide Array Sequence Analysis
Mood Disorders
Genes
Signal Transduction
Schizophrenia
Transcription Factors
Animal Models
Gene Expression
Brain

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Identifying candidate genes for mania and psychosis using a convergent functional genomics approach. / Niculescu, Alexander; Segal, D. S.; Kuczenski, R.; Barrett, T.; Hauger, R.; Kelsoe, J. R.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 96, No. 4, 07.08.2000, p. 481.

Research output: Contribution to journalArticle

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