We are using amphetamine treatments of rats as an animal model for mania and psychosis. Specific brain regions are analyzed comprehensively for changes in gene expression using oligonucleotide GeneChip microarrays. The data is then matched against human genomic loci associated with bipolar disorders and schizophrenia. Our results so far using this convergent approach have identified several candidate genes -signal transduction molecules, transcription factors that may be involved in the pathogenesis of mood disorders and psychosis.
|Original language||English (US)|
|Number of pages||1|
|Journal||American Journal of Medical Genetics - Neuropsychiatric Genetics|
|State||Published - Aug 7 2000|
ASJC Scopus subject areas
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience