Identity profiling of cell surface markers by multiplex gold nanorod probes

Chenxu Yu, Harikrishna Nakshatri, Joseph Irudayaraj

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Gold nanorod molecular probes (GNrMPs) were designed and fabricated for multiplex identification of cell surface markers in HBECs. Cells were probed directly using dark field microscopy integrated with a spectral imager for simultaneous detection of up to three surface markers. The immunophenotype composition of these cell lines indicative of their metastasis potential was assessed using the GNrMPs. The technique has the potential to become an important tool for diagnosis and prognosis of breast and other cancers.

Original languageEnglish
Pages (from-to)2300-2306
Number of pages7
JournalNano Letters
Volume7
Issue number8
DOIs
StatePublished - Aug 2007

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Molecular Probes
Nanorods
Gold
markers
nanorods
gold
prognosis
probes
metastasis
cells
cultured cells
Image sensors
breast
Microscopic examination
cancer
Cells
microscopy
Chemical analysis

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Identity profiling of cell surface markers by multiplex gold nanorod probes. / Yu, Chenxu; Nakshatri, Harikrishna; Irudayaraj, Joseph.

In: Nano Letters, Vol. 7, No. 8, 08.2007, p. 2300-2306.

Research output: Contribution to journalArticle

Yu, Chenxu ; Nakshatri, Harikrishna ; Irudayaraj, Joseph. / Identity profiling of cell surface markers by multiplex gold nanorod probes. In: Nano Letters. 2007 ; Vol. 7, No. 8. pp. 2300-2306.
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