IGF-I and blood vessels - Implications for microvascular and macrovascular disease

M. Grant, G. L. King

Research output: Contribution to journalReview article

9 Scopus citations


A large number of studies have been performed at in vivo and in vitro levels to study the production, effect, and receptors of insulin-like growth factors I and II (IGF-I and IGF-II), In this report, the production of IGFs and their binding proteins is described from various types of vascular cells. In addition, receptors for IGF-I and IGF-II and their structures are reported to be similar to known vascular cells, In the area of biological activities, however, the effects of IGFs on vascular cells are multiple, One unusual function of the IGF-I receptor in endothelial cells could be the involvement of transcytosis of IGF-I across the endothelium. In addition, IGF can stimulate both metabolic and growth-promoting activities in cultured vascular cells. However, IGFs' biological effects appear to be much more potent in microvascular cells than in macrovascular cells, The interest in IGFs' effect on vascular cells is derived mainly from the possibility that they could be responsible for some of the vascular complications of diabetes, The clinical and animal studies involving IGFs and their possible roles in the development of diabetic proliferative retinopathy and glomerular sclerosis have been reviewed. In summary, this review provides extensive evidence that IGF-I and IGF-II and their binding proteins can have substantial effects on the vascular cells with regard to metabolism, growth, and angiogenesis. Evidence for their involvement in diabetic vascular diseases, however, has not been clearly established,

Original languageEnglish (US)
Pages (from-to)113-128
Number of pages16
JournalDiabetes Reviews
Issue number1
StatePublished - May 3 1995

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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