IGF-I and postnatal growth of weaver mutant mice

Weiguo Yao, Jin Zhong, Clifford J. Rosen, Janet M. Hock, Wei Hua Lee

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

IGF-I is an anabolic growth factor essential for growth and development, both as a mediator of growth hormone (GH) action and as a local stimulator of cell proliferation and differentiation. Although the importance of IGF-I in postnatal growth has been studied for several decades, its functions in pathological states are not fully understood. The weaver (wv) mutant mouse is a commonly used model for studying hereditary cerebellar ataxia and provides us with an opportunity to study the function of IGF-I in postnatal growth during neurodegeneration. In prepubertal wv mice, we found a parallel decrease in body weight and serum IGF-I. This parallel relationship was maintained in females, but not in males, as wv mice entered puberty. Interestingly, we found an increase in the levels of circulating IGF-I and hepatic mRNA preceded the catch-up of body weight of pubertal male wv mice. The increase in IGF-I levels coincided with a surge of circulating androgen at the onset of male puberty, suggesting that androgen might trigger the increase in IGF-I production in the pubertal and adult male wv mice. Overall, our results support the concept that IGF-I plays an important role in postnatal growth during and after neurodegeneration of wv mice. In addition, IGF-I's regulation of systemic growth during and after puberty is likely modulated by androgen in male wv mice.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalEndocrine
Volume26
Issue number2
DOIs
StatePublished - Mar 1 2005

Keywords

  • Growth
  • IGF-I
  • Puberty
  • Weaver mice

ASJC Scopus subject areas

  • Endocrinology

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    Yao, W., Zhong, J., Rosen, C. J., Hock, J. M., & Lee, W. H. (2005). IGF-I and postnatal growth of weaver mutant mice. Endocrine, 26(2), 117-125. https://doi.org/10.1385/ENDO:26:2:117