Abstract
IGF-I is an anabolic growth factor essential for growth and development, both as a mediator of growth hormone (GH) action and as a local stimulator of cell proliferation and differentiation. Although the importance of IGF-I in postnatal growth has been studied for several decades, its functions in pathological states are not fully understood. The weaver (wv) mutant mouse is a commonly used model for studying hereditary cerebellar ataxia and provides us with an opportunity to study the function of IGF-I in postnatal growth during neurodegeneration. In prepubertal wv mice, we found a parallel decrease in body weight and serum IGF-I. This parallel relationship was maintained in females, but not in males, as wv mice entered puberty. Interestingly, we found an increase in the levels of circulating IGF-I and hepatic mRNA preceded the catch-up of body weight of pubertal male wv mice. The increase in IGF-I levels coincided with a surge of circulating androgen at the onset of male puberty, suggesting that androgen might trigger the increase in IGF-I production in the pubertal and adult male wv mice. Overall, our results support the concept that IGF-I plays an important role in postnatal growth during and after neurodegeneration of wv mice. In addition, IGF-I's regulation of systemic growth during and after puberty is likely modulated by androgen in male wv mice.
| Original language | English |
|---|---|
| Pages (from-to) | 117-125 |
| Number of pages | 9 |
| Journal | Endocrine |
| Volume | 26 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2005 |
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Keywords
- Growth
- IGF-I
- Puberty
- Weaver mice
ASJC Scopus subject areas
- Endocrinology
Cite this
IGF-I and postnatal growth of weaver mutant mice. / Yao, Weiguo; Zhong, Jin; Rosen, Clifford J.; Hock, Janet M.; Lee, Wei Hua.
In: Endocrine, Vol. 26, No. 2, 03.2005, p. 117-125.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IGF-I and postnatal growth of weaver mutant mice
AU - Yao, Weiguo
AU - Zhong, Jin
AU - Rosen, Clifford J.
AU - Hock, Janet M.
AU - Lee, Wei Hua
PY - 2005/3
Y1 - 2005/3
N2 - IGF-I is an anabolic growth factor essential for growth and development, both as a mediator of growth hormone (GH) action and as a local stimulator of cell proliferation and differentiation. Although the importance of IGF-I in postnatal growth has been studied for several decades, its functions in pathological states are not fully understood. The weaver (wv) mutant mouse is a commonly used model for studying hereditary cerebellar ataxia and provides us with an opportunity to study the function of IGF-I in postnatal growth during neurodegeneration. In prepubertal wv mice, we found a parallel decrease in body weight and serum IGF-I. This parallel relationship was maintained in females, but not in males, as wv mice entered puberty. Interestingly, we found an increase in the levels of circulating IGF-I and hepatic mRNA preceded the catch-up of body weight of pubertal male wv mice. The increase in IGF-I levels coincided with a surge of circulating androgen at the onset of male puberty, suggesting that androgen might trigger the increase in IGF-I production in the pubertal and adult male wv mice. Overall, our results support the concept that IGF-I plays an important role in postnatal growth during and after neurodegeneration of wv mice. In addition, IGF-I's regulation of systemic growth during and after puberty is likely modulated by androgen in male wv mice.
AB - IGF-I is an anabolic growth factor essential for growth and development, both as a mediator of growth hormone (GH) action and as a local stimulator of cell proliferation and differentiation. Although the importance of IGF-I in postnatal growth has been studied for several decades, its functions in pathological states are not fully understood. The weaver (wv) mutant mouse is a commonly used model for studying hereditary cerebellar ataxia and provides us with an opportunity to study the function of IGF-I in postnatal growth during neurodegeneration. In prepubertal wv mice, we found a parallel decrease in body weight and serum IGF-I. This parallel relationship was maintained in females, but not in males, as wv mice entered puberty. Interestingly, we found an increase in the levels of circulating IGF-I and hepatic mRNA preceded the catch-up of body weight of pubertal male wv mice. The increase in IGF-I levels coincided with a surge of circulating androgen at the onset of male puberty, suggesting that androgen might trigger the increase in IGF-I production in the pubertal and adult male wv mice. Overall, our results support the concept that IGF-I plays an important role in postnatal growth during and after neurodegeneration of wv mice. In addition, IGF-I's regulation of systemic growth during and after puberty is likely modulated by androgen in male wv mice.
KW - Growth
KW - IGF-I
KW - Puberty
KW - Weaver mice
UR - http://www.scopus.com/inward/record.url?scp=23844431702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23844431702&partnerID=8YFLogxK
U2 - 10.1385/ENDO:26:2:117
DO - 10.1385/ENDO:26:2:117
M3 - Article
C2 - 15888923
AN - SCOPUS:23844431702
VL - 26
SP - 117
EP - 125
JO - Endocrine
JF - Endocrine
SN - 1355-008X
IS - 2
ER -