IGF-I and postnatal growth of weaver mutant mice

Weiguo Yao, Jin Zhong, Clifford J. Rosen, Janet M. Hock, Wei Hua Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

IGF-I is an anabolic growth factor essential for growth and development, both as a mediator of growth hormone (GH) action and as a local stimulator of cell proliferation and differentiation. Although the importance of IGF-I in postnatal growth has been studied for several decades, its functions in pathological states are not fully understood. The weaver (wv) mutant mouse is a commonly used model for studying hereditary cerebellar ataxia and provides us with an opportunity to study the function of IGF-I in postnatal growth during neurodegeneration. In prepubertal wv mice, we found a parallel decrease in body weight and serum IGF-I. This parallel relationship was maintained in females, but not in males, as wv mice entered puberty. Interestingly, we found an increase in the levels of circulating IGF-I and hepatic mRNA preceded the catch-up of body weight of pubertal male wv mice. The increase in IGF-I levels coincided with a surge of circulating androgen at the onset of male puberty, suggesting that androgen might trigger the increase in IGF-I production in the pubertal and adult male wv mice. Overall, our results support the concept that IGF-I plays an important role in postnatal growth during and after neurodegeneration of wv mice. In addition, IGF-I's regulation of systemic growth during and after puberty is likely modulated by androgen in male wv mice.

Original languageEnglish
Pages (from-to)117-125
Number of pages9
JournalEndocrine
Volume26
Issue number2
DOIs
StatePublished - Mar 2005

Fingerprint

Neurologic Mutant Mice
Insulin-Like Growth Factor I
Growth
Puberty
Androgens
Body Weight
Spinocerebellar Degenerations
Cerebellar Ataxia
Growth and Development
Growth Hormone
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Cell Proliferation
Messenger RNA
Liver

Keywords

  • Growth
  • IGF-I
  • Puberty
  • Weaver mice

ASJC Scopus subject areas

  • Endocrinology

Cite this

Yao, W., Zhong, J., Rosen, C. J., Hock, J. M., & Lee, W. H. (2005). IGF-I and postnatal growth of weaver mutant mice. Endocrine, 26(2), 117-125. https://doi.org/10.1385/ENDO:26:2:117

IGF-I and postnatal growth of weaver mutant mice. / Yao, Weiguo; Zhong, Jin; Rosen, Clifford J.; Hock, Janet M.; Lee, Wei Hua.

In: Endocrine, Vol. 26, No. 2, 03.2005, p. 117-125.

Research output: Contribution to journalArticle

Yao, W, Zhong, J, Rosen, CJ, Hock, JM & Lee, WH 2005, 'IGF-I and postnatal growth of weaver mutant mice', Endocrine, vol. 26, no. 2, pp. 117-125. https://doi.org/10.1385/ENDO:26:2:117
Yao W, Zhong J, Rosen CJ, Hock JM, Lee WH. IGF-I and postnatal growth of weaver mutant mice. Endocrine. 2005 Mar;26(2):117-125. https://doi.org/10.1385/ENDO:26:2:117
Yao, Weiguo ; Zhong, Jin ; Rosen, Clifford J. ; Hock, Janet M. ; Lee, Wei Hua. / IGF-I and postnatal growth of weaver mutant mice. In: Endocrine. 2005 ; Vol. 26, No. 2. pp. 117-125.
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