Image-based biomimetic approach to reconstruction of the temporomandibular joint

Stephen E. Feinberg, Scott J. Hollister, John W. Halloran, T.M. Gabriel Chu, Paul H. Krebsbach

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

This article will present an image-based approach to the designing and manufacturing of biomimetic tissue engineered temporomandibular (TMJ) condylar prosthesis. Our vision of a tissue-engineered TMJ prosthesis utilizes a 3-D designed and manufactured biodegradable scaffold shaped similar to a condylar head and neck, i.e. a condylar-ramus unit (CRU). The fabricated CRU scaffold can be constructed with a specific intra-architectural design such that it will enhance the formation of tissue from implanted cells placed within its interstices. These biologic cues could influence scaffold-implanted mesen-chymal stem cells (MSC) or bone marrow stromal cells (BMSC) to form a fibrocartilaginous joint surface, or cap, on top of a bony strut, similar to a costochondral rib graft (CCRG), which could be fixed to the mandibular ramus. This new approach to tissue engineering a TMJ would be advantageous because of its patient site-specific anatomical configuration as well as its potential ability to adapt to the loading forces placed on it during function.

Original languageEnglish (US)
Pages (from-to)309-321
Number of pages13
JournalCells Tissues Organs
Volume169
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Biomimetics
Temporomandibular Joint
Prostheses and Implants
Aptitude
Ribs
Tissue Engineering
Mesenchymal Stromal Cells
Cues
Neck
Stem Cells
Joints
Transplants

Keywords

  • Biomimetic
  • Imaged-based
  • Reconstruction
  • Temporomandibular joint

ASJC Scopus subject areas

  • Anatomy

Cite this

Feinberg, S. E., Hollister, S. J., Halloran, J. W., Chu, T. M. G., & Krebsbach, P. H. (2001). Image-based biomimetic approach to reconstruction of the temporomandibular joint. Cells Tissues Organs, 169(3), 309-321. https://doi.org/10.1159/000047896

Image-based biomimetic approach to reconstruction of the temporomandibular joint. / Feinberg, Stephen E.; Hollister, Scott J.; Halloran, John W.; Chu, T.M. Gabriel; Krebsbach, Paul H.

In: Cells Tissues Organs, Vol. 169, No. 3, 2001, p. 309-321.

Research output: Contribution to journalArticle

Feinberg, SE, Hollister, SJ, Halloran, JW, Chu, TMG & Krebsbach, PH 2001, 'Image-based biomimetic approach to reconstruction of the temporomandibular joint', Cells Tissues Organs, vol. 169, no. 3, pp. 309-321. https://doi.org/10.1159/000047896
Feinberg, Stephen E. ; Hollister, Scott J. ; Halloran, John W. ; Chu, T.M. Gabriel ; Krebsbach, Paul H. / Image-based biomimetic approach to reconstruction of the temporomandibular joint. In: Cells Tissues Organs. 2001 ; Vol. 169, No. 3. pp. 309-321.
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