Image guided interactive volume visualization for confocal microscopy data exploration

Tom Biddlecome, Shiaofen Fang, Ken Dunn, Mihran Tuceryan

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations


3D microscopy visualization has the potential of playing a significant role in the study of 3D cellular structures in biomedical research. Such potential, however, has not been fully realized due to the difficulties of current visualization methods in coping with the unique nature of microscopy image volumes, such as low image contrast, noise and unknown transfer functions. In this paper, we present a new 3D microscopy imaging approach that integrates volume visualization and 3D image processing techniques for interactive 3D data exploration and analysis. By embedding 3D image enhancement procedures into the volume visualization pipeline, we are able to automatically generate image-dependent transfer functions to reveal subtle features that are otherwise difficult to visualize. It allows the users to interactively manipulate a small number of parameters to achieve desired visualization effects. Other 3D image processing techniques, such as quantification and segmentation, may also be integrated within the data exploration process for interactive image analysis.

Original languageEnglish (US)
Pages (from-to)130-140
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Dec 1 1998
EventMedical Imaging 1998: Image Display - San Diego, CA, United States
Duration: Feb 22 1998Feb 24 1998


  • 3D microscopy imaging
  • Image enhancement
  • Image processing
  • Volume visualization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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