Since the 1980s, when the first clinical brain magnetic resonance image (MRI) was taken, technical advances in MRI have resulted in a dramatic improvement of image quality in neuroimaging. Major innovations in MR technology have resulted in formidable advances in the field of structural neuroimaging of neurodegenerative disorders. Due to improved resolution, three-dimensional (3D) acquisition, high-field (3T-7T) MRI technology with acceptable duration and acquisition time, as well as innovative techniques for analysis of MR images, it is now possible to study the subtle anatomical changes in the brains of Parkinson’s disease (PD) subjects in vivo. Repeated scanning has made it possible to follow the disease process over time. It is increasingly acknowledged that much of the disability of PD arises from non-motor complications, including cognitive and behavioral problems, sleep disturbances, and more. In a study using the health-related quality of life (HRQoL) instrument, clinical factors such as depression, sleep disorders, and fatigue showed the highest predictive value for worsened HRQoL .
|Original language||English (US)|
|Title of host publication||Neuropsychiatric and Cognitive Changes in Parkinson's Disease and Related Movement Disorders|
|Subtitle of host publication||Diagnosis and Management|
|Publisher||Cambridge University Press|
|Number of pages||16|
|State||Published - Jan 1 2010|
ASJC Scopus subject areas