Imaging of the left anterior descending coronary artery by high-frequency transthoracic and epicardial echocardiography

Irmina Gradus-Pizlo, Harvey Feigenbaum

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Left anterior descending coronary artery (LAD) wall thickness and external diameter are significantly increased in patients with coronary artery disease compared with normal subjects. High-resolution, 2-dimensional transthoracic echocardiography (HR-2DTTE) can be used to measure LAD wall thickness and is sensitive enough to detect these differences. However, HR-2DTTE measurements of the LAD wall thickness are larger than measurements obtained by intravascular ultrasound and histology. We hypothesize that this difference is due to inclusion of the third vascular layer, which may represent adventitia, by HR-2DTTE, and that this layer must be increasing in thickness with the development of atherosclerosis. We evaluated the contribution of this third layer to the wall thickness of the normal and atherosclerotic LAD imaged by HR-2DTTE using high-frequency epicardial echocardiography (HFEE). Thirteen patients with coronary atherosclerosis and 5 patients with normal coronary arteries underwent preoperative HR-2DTTE and intraoperative HFEE. HR-2DTTE and HFEE measurements of the wall thickness correlated well. The wall thickness was significantly greater in patients with coronary atherosclerosis than in patients with normal coronary arteries by both HR-2DTTE and HFEE. With HFEE, the average intima plus media thickness and the average thickness of adventitia were greater in patients with coronary atherosclerosis than in patients with normal coronary arteries. A third vascular layer, which likely includes adventitia, represents a significant portion of the LAD wall thickness imaged by HR-2DTTE and HFEE, and its thickness increases significantly with the development of atherosclerosis.

Original languageEnglish
JournalThe American Journal of Cardiology
Volume90
Issue number10 SUPPL. 3
StatePublished - Nov 21 2002

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Echocardiography
Coronary Vessels
Adventitia
Coronary Artery Disease
Blood Vessels
Atherosclerosis
Histology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Imaging of the left anterior descending coronary artery by high-frequency transthoracic and epicardial echocardiography. / Gradus-Pizlo, Irmina; Feigenbaum, Harvey.

In: The American Journal of Cardiology, Vol. 90, No. 10 SUPPL. 3, 21.11.2002.

Research output: Contribution to journalArticle

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