Imaging the progression of intra-tumor heterogeneity in prostate and ovarian xenografts using dynamic contrast-enhanced CT

Keith M. Stantz, Yun Liang, Xiong Li, Chinghai Kao, Rosemary Steinmetz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

The purpose of this study is to measure the progressive intra-tumor heterogeneous physiological states for prostate (CWRrv) and ovarian (SKOV3x) xenograft mouse models. Dynamic contrast-enhanced CT was used to measure the change in a tumor's physiological state when transitioning from stage I (<7 mm diameter) to stage II (7-20 mm diameter). Images from stage I tumors are in the initial stages of angiogenesis: neovasculature growth. A radial heterogeneity begins to form with signs of angiogenic activity throughout the tumor. Stage II tumors develop both a saccular heterogeneity and a strong radial heterogeneity between periphery and core consistent with the effects of inflammatory and maturation processes. Imaging intra-tumor heterogeneity has the potential to track tumor stage and to be used as predictive factor in determining mortality rates.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages1883-1886
Number of pages4
Volume7 VOLS
StatePublished - 2005
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: Sep 1 2005Sep 4 2005

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period9/1/059/4/05

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Heterografts
Tumors
Imaging techniques

ASJC Scopus subject areas

  • Bioengineering

Cite this

Stantz, K. M., Liang, Y., Li, X., Kao, C., & Steinmetz, R. (2005). Imaging the progression of intra-tumor heterogeneity in prostate and ovarian xenografts using dynamic contrast-enhanced CT. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 7 VOLS, pp. 1883-1886). [1616818]

Imaging the progression of intra-tumor heterogeneity in prostate and ovarian xenografts using dynamic contrast-enhanced CT. / Stantz, Keith M.; Liang, Yun; Li, Xiong; Kao, Chinghai; Steinmetz, Rosemary.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 7 VOLS 2005. p. 1883-1886 1616818.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Stantz, KM, Liang, Y, Li, X, Kao, C & Steinmetz, R 2005, Imaging the progression of intra-tumor heterogeneity in prostate and ovarian xenografts using dynamic contrast-enhanced CT. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 7 VOLS, 1616818, pp. 1883-1886, 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005, Shanghai, China, 9/1/05.
Stantz KM, Liang Y, Li X, Kao C, Steinmetz R. Imaging the progression of intra-tumor heterogeneity in prostate and ovarian xenografts using dynamic contrast-enhanced CT. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 7 VOLS. 2005. p. 1883-1886. 1616818
Stantz, Keith M. ; Liang, Yun ; Li, Xiong ; Kao, Chinghai ; Steinmetz, Rosemary. / Imaging the progression of intra-tumor heterogeneity in prostate and ovarian xenografts using dynamic contrast-enhanced CT. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 7 VOLS 2005. pp. 1883-1886
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