Imidazoline compounds inhibit KATP channels in guinea pig ventricular myocytes

Kevin Lee, William Groh, T. Anne Blair, James G. Maylie, John P. Adelman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Phentolamine and related imidazolines inhibit KATP channel activity in the pancreatic β cell. In the present study, the effects of several imidazoline-based compounds were examined upon KATP channel activity in guinea pig ventricular myocytes. Phentolamine produced a potent inhibition of KATP channel activity when examined in either excised inside-out patches or in the whole-cell configuration. This effect was unrelated to phentolamine's ability to antagonise α-adrenoceptors since the non-selective α-adrenoceptor antagonists, benextramine and phenoxybenzamine, failed to affect channel activity. Furthermore, the α-adrenoceptor agonist clonidine together with several related imidazolines inhibited channel activity. This suggests that imidazoline compounds modulate KATP channel activity in guinea pig ventricular myocytes and this may have clinical implications for the use of such agents as hypoglycemic drugs.

Original languageEnglish (US)
Pages (from-to)309-312
Number of pages4
JournalEuropean Journal of Pharmacology
Volume285
Issue number3
DOIs
StatePublished - Oct 24 1995
Externally publishedYes

Fingerprint

Imidazolines
KATP Channels
Muscle Cells
Phentolamine
Guinea Pigs
Adrenergic Receptors
Phenoxybenzamine
Clonidine
Hypoglycemic Agents

Keywords

  • (Guinea-pig)
  • Cardiac myocyte
  • Imidazoline
  • K channel

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Imidazoline compounds inhibit KATP channels in guinea pig ventricular myocytes. / Lee, Kevin; Groh, William; Blair, T. Anne; Maylie, James G.; Adelman, John P.

In: European Journal of Pharmacology, Vol. 285, No. 3, 24.10.1995, p. 309-312.

Research output: Contribution to journalArticle

Lee, Kevin ; Groh, William ; Blair, T. Anne ; Maylie, James G. ; Adelman, John P. / Imidazoline compounds inhibit KATP channels in guinea pig ventricular myocytes. In: European Journal of Pharmacology. 1995 ; Vol. 285, No. 3. pp. 309-312.
@article{34304962ed8640f0ae69e8d0c0740a27,
title = "Imidazoline compounds inhibit KATP channels in guinea pig ventricular myocytes",
abstract = "Phentolamine and related imidazolines inhibit KATP channel activity in the pancreatic β cell. In the present study, the effects of several imidazoline-based compounds were examined upon KATP channel activity in guinea pig ventricular myocytes. Phentolamine produced a potent inhibition of KATP channel activity when examined in either excised inside-out patches or in the whole-cell configuration. This effect was unrelated to phentolamine's ability to antagonise α-adrenoceptors since the non-selective α-adrenoceptor antagonists, benextramine and phenoxybenzamine, failed to affect channel activity. Furthermore, the α-adrenoceptor agonist clonidine together with several related imidazolines inhibited channel activity. This suggests that imidazoline compounds modulate KATP channel activity in guinea pig ventricular myocytes and this may have clinical implications for the use of such agents as hypoglycemic drugs.",
keywords = "(Guinea-pig), Cardiac myocyte, Imidazoline, K channel",
author = "Kevin Lee and William Groh and Blair, {T. Anne} and Maylie, {James G.} and Adelman, {John P.}",
year = "1995",
month = "10",
day = "24",
doi = "10.1016/0014-2999(95)00525-P",
language = "English (US)",
volume = "285",
pages = "309--312",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Imidazoline compounds inhibit KATP channels in guinea pig ventricular myocytes

AU - Lee, Kevin

AU - Groh, William

AU - Blair, T. Anne

AU - Maylie, James G.

AU - Adelman, John P.

PY - 1995/10/24

Y1 - 1995/10/24

N2 - Phentolamine and related imidazolines inhibit KATP channel activity in the pancreatic β cell. In the present study, the effects of several imidazoline-based compounds were examined upon KATP channel activity in guinea pig ventricular myocytes. Phentolamine produced a potent inhibition of KATP channel activity when examined in either excised inside-out patches or in the whole-cell configuration. This effect was unrelated to phentolamine's ability to antagonise α-adrenoceptors since the non-selective α-adrenoceptor antagonists, benextramine and phenoxybenzamine, failed to affect channel activity. Furthermore, the α-adrenoceptor agonist clonidine together with several related imidazolines inhibited channel activity. This suggests that imidazoline compounds modulate KATP channel activity in guinea pig ventricular myocytes and this may have clinical implications for the use of such agents as hypoglycemic drugs.

AB - Phentolamine and related imidazolines inhibit KATP channel activity in the pancreatic β cell. In the present study, the effects of several imidazoline-based compounds were examined upon KATP channel activity in guinea pig ventricular myocytes. Phentolamine produced a potent inhibition of KATP channel activity when examined in either excised inside-out patches or in the whole-cell configuration. This effect was unrelated to phentolamine's ability to antagonise α-adrenoceptors since the non-selective α-adrenoceptor antagonists, benextramine and phenoxybenzamine, failed to affect channel activity. Furthermore, the α-adrenoceptor agonist clonidine together with several related imidazolines inhibited channel activity. This suggests that imidazoline compounds modulate KATP channel activity in guinea pig ventricular myocytes and this may have clinical implications for the use of such agents as hypoglycemic drugs.

KW - (Guinea-pig)

KW - Cardiac myocyte

KW - Imidazoline

KW - K channel

UR - http://www.scopus.com/inward/record.url?scp=0028885141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028885141&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(95)00525-P

DO - 10.1016/0014-2999(95)00525-P

M3 - Article

VL - 285

SP - 309

EP - 312

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 3

ER -