Imidazoline compounds inhibit KATP channels in guinea pig ventricular myocytes

Kevin Lee, William J. Groh, T. Anne Blair, James G. Maylie, John P. Adelman

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Phentolamine and related imidazolines inhibit KATP channel activity in the pancreatic β cell. In the present study, the effects of several imidazoline-based compounds were examined upon KATP channel activity in guinea pig ventricular myocytes. Phentolamine produced a potent inhibition of KATP channel activity when examined in either excised inside-out patches or in the whole-cell configuration. This effect was unrelated to phentolamine's ability to antagonise α-adrenoceptors since the non-selective α-adrenoceptor antagonists, benextramine and phenoxybenzamine, failed to affect channel activity. Furthermore, the α-adrenoceptor agonist clonidine together with several related imidazolines inhibited channel activity. This suggests that imidazoline compounds modulate KATP channel activity in guinea pig ventricular myocytes and this may have clinical implications for the use of such agents as hypoglycemic drugs.

Original languageEnglish (US)
Pages (from-to)309-312
Number of pages4
JournalEuropean Journal of Pharmacology
Volume285
Issue number3
DOIs
StatePublished - Oct 24 1995
Externally publishedYes

Keywords

  • (Guinea-pig)
  • Cardiac myocyte
  • Imidazoline
  • K channel

ASJC Scopus subject areas

  • Pharmacology

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