Immune-mediated diseases and immunodeficiencies associated with thymic epithelial neoplasms

Muhammad Rizwan Khawaja, Robert Nelson, Nicholas Miller, Sunil Badve, Elizabeth Loehrer, Magdalena Czader, Susan Perkins, Kenneth Kesler, Patrick Loehrer

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: This retrospective study aimed to characterize the clinical hematological and immunological features of patients with thymic epithelial neoplasms. Methods: From a cohort of 512 patients with thymic epithelial neoplasms, 79 patients diagnosed with autoimmune/immunodeficiency conditions or signs and/or symptoms suggesting an autoimmune or immunodeficiency state were evaluated by standard immunological and hematological testing. Results: Elevated percentages of CD2+, CD3+, and CD8+ lymphocytes were observed in 44 (57.1%), 33 (41.8%), and 32 (40.5%) patients. Low CD4+ and CD19+ percentages were observed in 25 (31.6%) and 36 (46.2%), respectively; CD4+:CD8+ ratios were inverted in 18 (22.8%). IgG, IgA, and IgM levels were low in 12 (15.8%), 9 (11.7%) and 15 (19.7%) patients, respectively. Patients with immunodeficiency condition(s) were more likely to have high CD8+ percentages (p=0.040), low CD19+ percentages (p=0.025), and/or inverted CD4+/CD8+ ratios (p=0.034). Patients with autoimmune condition(s) were more likely to have a high/normal CD4+ percentage (p=0.038). High CD2+ percentages were associated with lower mean IgG and IgA levels (p=0.030 and p=0.017, respectively). High CD3+ and CD8+ percentages were associated with lower mean IgA levels (p=0.046 and p=0.013, respectively). Low CD19+ percentages were associated with lower mean IgG and IgA levels (p=0.004 and p<0.001, respectively). Conclusion: Signs/symptoms and history of autoimmune and immunodeficiency conditions among patients with thymic epithelial neoplasms are associated with high frequencies of abnormalities in immunoglobulin levels and lymphocyte immunophenotypes, suggesting a role for their assessment.

Original languageEnglish
Pages (from-to)430-437
Number of pages8
JournalJournal of Clinical Immunology
Volume32
Issue number3
DOIs
StatePublished - Jun 2012

Fingerprint

Thymus Neoplasms
Glandular and Epithelial Neoplasms
Immune System Diseases
Immunoglobulin A
CD4-CD8 Ratio
Immunoglobulin G
Signs and Symptoms
Lymphocytes
Immunoglobulin M
Immunoglobulins
Retrospective Studies

Keywords

  • autoimmunity
  • immunodeficiency
  • immunoglobulin levels
  • lymphocyte immunophenotypes
  • Thymic epithelial neoplasms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immune-mediated diseases and immunodeficiencies associated with thymic epithelial neoplasms. / Khawaja, Muhammad Rizwan; Nelson, Robert; Miller, Nicholas; Badve, Sunil; Loehrer, Elizabeth; Czader, Magdalena; Perkins, Susan; Kesler, Kenneth; Loehrer, Patrick.

In: Journal of Clinical Immunology, Vol. 32, No. 3, 06.2012, p. 430-437.

Research output: Contribution to journalArticle

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abstract = "Introduction: This retrospective study aimed to characterize the clinical hematological and immunological features of patients with thymic epithelial neoplasms. Methods: From a cohort of 512 patients with thymic epithelial neoplasms, 79 patients diagnosed with autoimmune/immunodeficiency conditions or signs and/or symptoms suggesting an autoimmune or immunodeficiency state were evaluated by standard immunological and hematological testing. Results: Elevated percentages of CD2+, CD3+, and CD8+ lymphocytes were observed in 44 (57.1{\%}), 33 (41.8{\%}), and 32 (40.5{\%}) patients. Low CD4+ and CD19+ percentages were observed in 25 (31.6{\%}) and 36 (46.2{\%}), respectively; CD4+:CD8+ ratios were inverted in 18 (22.8{\%}). IgG, IgA, and IgM levels were low in 12 (15.8{\%}), 9 (11.7{\%}) and 15 (19.7{\%}) patients, respectively. Patients with immunodeficiency condition(s) were more likely to have high CD8+ percentages (p=0.040), low CD19+ percentages (p=0.025), and/or inverted CD4+/CD8+ ratios (p=0.034). Patients with autoimmune condition(s) were more likely to have a high/normal CD4+ percentage (p=0.038). High CD2+ percentages were associated with lower mean IgG and IgA levels (p=0.030 and p=0.017, respectively). High CD3+ and CD8+ percentages were associated with lower mean IgA levels (p=0.046 and p=0.013, respectively). Low CD19+ percentages were associated with lower mean IgG and IgA levels (p=0.004 and p<0.001, respectively). Conclusion: Signs/symptoms and history of autoimmune and immunodeficiency conditions among patients with thymic epithelial neoplasms are associated with high frequencies of abnormalities in immunoglobulin levels and lymphocyte immunophenotypes, suggesting a role for their assessment.",
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AU - Khawaja, Muhammad Rizwan

AU - Nelson, Robert

AU - Miller, Nicholas

AU - Badve, Sunil

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AU - Czader, Magdalena

AU - Perkins, Susan

AU - Kesler, Kenneth

AU - Loehrer, Patrick

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N2 - Introduction: This retrospective study aimed to characterize the clinical hematological and immunological features of patients with thymic epithelial neoplasms. Methods: From a cohort of 512 patients with thymic epithelial neoplasms, 79 patients diagnosed with autoimmune/immunodeficiency conditions or signs and/or symptoms suggesting an autoimmune or immunodeficiency state were evaluated by standard immunological and hematological testing. Results: Elevated percentages of CD2+, CD3+, and CD8+ lymphocytes were observed in 44 (57.1%), 33 (41.8%), and 32 (40.5%) patients. Low CD4+ and CD19+ percentages were observed in 25 (31.6%) and 36 (46.2%), respectively; CD4+:CD8+ ratios were inverted in 18 (22.8%). IgG, IgA, and IgM levels were low in 12 (15.8%), 9 (11.7%) and 15 (19.7%) patients, respectively. Patients with immunodeficiency condition(s) were more likely to have high CD8+ percentages (p=0.040), low CD19+ percentages (p=0.025), and/or inverted CD4+/CD8+ ratios (p=0.034). Patients with autoimmune condition(s) were more likely to have a high/normal CD4+ percentage (p=0.038). High CD2+ percentages were associated with lower mean IgG and IgA levels (p=0.030 and p=0.017, respectively). High CD3+ and CD8+ percentages were associated with lower mean IgA levels (p=0.046 and p=0.013, respectively). Low CD19+ percentages were associated with lower mean IgG and IgA levels (p=0.004 and p<0.001, respectively). Conclusion: Signs/symptoms and history of autoimmune and immunodeficiency conditions among patients with thymic epithelial neoplasms are associated with high frequencies of abnormalities in immunoglobulin levels and lymphocyte immunophenotypes, suggesting a role for their assessment.

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