Immune response of neonatal specific pathogen-free cats to experimental infection with Bartonella henselae

Lynn Guptill, Leonard Slater, Ching Ching Wu, Lawrence T. Glickman, Tsang Long Lin, David F. Welch, Julie Tobolski Crippen, Harm HogenEsch

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The purpose of this study was to determine whether neonatal cats develop and maintain a persistent bacteremia for longer than do adult cats with a normal mature immune system, and whether neonatal cats are susceptible to infection with Bartonella henselae by oral inoculation. Neonatal specific pathogen-free (SPF) cats were inoculated with B. henselae intradermally (n = 4) or orally (n = 5) or with 0.9% NaCl (n = 2). Blood was collected periodically through 16 weeks post-inoculation (PI) for serology, bacteriology and complete blood count. Cats inoculated orally or intradermally at 3-5 days of age were bacteremic through 12-16 weeks PI, similar to what is documented for adult cats inoculated intradermally or intravenously. One cat inoculated at age 2 weeks was bacteremic through 10 weeks PI; the other was not bacteremic. Intradermally inoculated neonatal cats produced serum IgG antibodies to B. henselae but orally inoculated neonatal cats did not. Infected cats with and without serum IgG antibodies to B. henselae became blood-culture negative simultaneously, suggesting that IgG is not required to clear bacteremia.

Original languageEnglish (US)
Pages (from-to)233-243
Number of pages11
JournalVeterinary Immunology and Immunopathology
Volume71
Issue number3-4
DOIs
StatePublished - Nov 30 1999
Externally publishedYes

Fingerprint

Bartonella henselae
Specific Pathogen-Free Organisms
Cats
immune response
cats
pathogens
Infection
infection
bacteremia
Immunoglobulin G
Bacteremia
blood serum
blood
Bacteriology
bacteriology
antibodies
Blood Cell Count
Antibodies
biological resistance
Serology

Keywords

  • Bartonella henselae
  • Cats
  • Immune response
  • Immunity
  • Immunoglobulin
  • Neonate

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Cite this

Immune response of neonatal specific pathogen-free cats to experimental infection with Bartonella henselae. / Guptill, Lynn; Slater, Leonard; Wu, Ching Ching; Glickman, Lawrence T.; Lin, Tsang Long; Welch, David F.; Crippen, Julie Tobolski; HogenEsch, Harm.

In: Veterinary Immunology and Immunopathology, Vol. 71, No. 3-4, 30.11.1999, p. 233-243.

Research output: Contribution to journalArticle

Guptill, Lynn ; Slater, Leonard ; Wu, Ching Ching ; Glickman, Lawrence T. ; Lin, Tsang Long ; Welch, David F. ; Crippen, Julie Tobolski ; HogenEsch, Harm. / Immune response of neonatal specific pathogen-free cats to experimental infection with Bartonella henselae. In: Veterinary Immunology and Immunopathology. 1999 ; Vol. 71, No. 3-4. pp. 233-243.
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