Immunobiology of liver xenotransplantation

Burcin Ekser, Christopher Burlak, Joshua P. Waldman, Andrew J. Lutz, Leela L. Paris, Massimiliano Veroux, Simon C. Robson, Michael A. Rees, David Ayares, Bruno Gridelli, A. Joseph Tector, David KC Cooper

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Pigs are currently the preferred species for future organ xenotransplantation. With advances in the development of genetically modified pigs, clinical xenotransplantation is becoming closer to reality. In preclinical studies (pig-to-nonhuman primate), the xenotransplantation of livers from pigs transgenic for human CD55 or from α1,3-galactosyltransferase gene-knockout pigs+/- transgenic for human CD46, is associated with survival of approximately 7-9 days. Although hepatic function, including coagulation, has proved to be satisfactory, the immediate development of thrombocytopenia is very limiting for pig liver xenotransplantation even as a 'bridge' to allotransplantation. Current studies are directed to understand the immunobiology of platelet activation, aggregation and phagocytosis, in particular the interaction between platelets and liver sinusoidal endothelial cells, hepatocytes and Kupffer cells, toward identifying interventions that may enable clinical application.

Original languageEnglish
Pages (from-to)621-634
Number of pages14
JournalExpert Review of Clinical Immunology
Volume8
Issue number7
DOIs
StatePublished - Sep 2012

Fingerprint

Heterologous Transplantation
Swine
Liver
Galactosyltransferases
Gene Knockout Techniques
Kupffer Cells
Platelet Activation
Platelet Aggregation
Phagocytosis
Thrombocytopenia
Primates
Hepatocytes
Blood Platelets
Endothelial Cells
Survival

Keywords

  • α1,3-galactosyltransferase gene-knockout
  • hCD46
  • liver
  • liver failure
  • nonhuman primate
  • pig
  • xenotransplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Ekser, B., Burlak, C., Waldman, J. P., Lutz, A. J., Paris, L. L., Veroux, M., ... Cooper, D. KC. (2012). Immunobiology of liver xenotransplantation. Expert Review of Clinical Immunology, 8(7), 621-634. https://doi.org/10.1586/eci.12.56

Immunobiology of liver xenotransplantation. / Ekser, Burcin; Burlak, Christopher; Waldman, Joshua P.; Lutz, Andrew J.; Paris, Leela L.; Veroux, Massimiliano; Robson, Simon C.; Rees, Michael A.; Ayares, David; Gridelli, Bruno; Tector, A. Joseph; Cooper, David KC.

In: Expert Review of Clinical Immunology, Vol. 8, No. 7, 09.2012, p. 621-634.

Research output: Contribution to journalArticle

Ekser, B, Burlak, C, Waldman, JP, Lutz, AJ, Paris, LL, Veroux, M, Robson, SC, Rees, MA, Ayares, D, Gridelli, B, Tector, AJ & Cooper, DKC 2012, 'Immunobiology of liver xenotransplantation', Expert Review of Clinical Immunology, vol. 8, no. 7, pp. 621-634. https://doi.org/10.1586/eci.12.56
Ekser B, Burlak C, Waldman JP, Lutz AJ, Paris LL, Veroux M et al. Immunobiology of liver xenotransplantation. Expert Review of Clinical Immunology. 2012 Sep;8(7):621-634. https://doi.org/10.1586/eci.12.56
Ekser, Burcin ; Burlak, Christopher ; Waldman, Joshua P. ; Lutz, Andrew J. ; Paris, Leela L. ; Veroux, Massimiliano ; Robson, Simon C. ; Rees, Michael A. ; Ayares, David ; Gridelli, Bruno ; Tector, A. Joseph ; Cooper, David KC. / Immunobiology of liver xenotransplantation. In: Expert Review of Clinical Immunology. 2012 ; Vol. 8, No. 7. pp. 621-634.
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