Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells

Stephen T. Smiley, Mark Kaplan, Michael J. Grusby

Research output: Contribution to journalArticle

419 Citations (Scopus)

Abstract

A lymphocyte population that expresses surface markers found on T cells and natural killer (NK) cells secretes large amounts of interleukin-4 (IL-4) immediately after T cell receptor ligation. These NK-like T cells are thus thought to be important for the initiation of type 2 T helper cell (T(H)2) responses. CD1-deficient mice were found to lack this lymphocyte subset, but they could nevertheless mount a protypical T(H)2 response; after immunization with antibody to immunoglobulin D (IgD), CD1-deficient mice produced IgE. Thus, although dependent on CD1 for their development, IL-4-secreting NK- like T cells are not required for T(H)2 responses.

Original languageEnglish (US)
Pages (from-to)977-979
Number of pages3
JournalScience
Volume275
Issue number5302
DOIs
StatePublished - Feb 14 1997
Externally publishedYes

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Natural Killer T-Cells
Interleukin-4
Immunoglobulin E
Immunoglobulin D
Th2 Cells
Lymphocyte Subsets
T-Cell Antigen Receptor
Natural Killer Cells
Ligation
Immunization
Lymphocytes
T-Lymphocytes
Antibodies
Population

ASJC Scopus subject areas

  • General

Cite this

Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. / Smiley, Stephen T.; Kaplan, Mark; Grusby, Michael J.

In: Science, Vol. 275, No. 5302, 14.02.1997, p. 977-979.

Research output: Contribution to journalArticle

Smiley, Stephen T. ; Kaplan, Mark ; Grusby, Michael J. / Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. In: Science. 1997 ; Vol. 275, No. 5302. pp. 977-979.
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