Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells

Stephen T. Smiley, Mark H. Kaplan, Michael J. Grusby

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Abstract

A lymphocyte population that expresses surface markers found on T cells and natural killer (NK) cells secretes large amounts of interleukin-4 (IL-4) immediately after T cell receptor ligation. These NK-like T cells are thus thought to be important for the initiation of type 2 T helper cell (T(H)2) responses. CD1-deficient mice were found to lack this lymphocyte subset, but they could nevertheless mount a protypical T(H)2 response; after immunization with antibody to immunoglobulin D (IgD), CD1-deficient mice produced IgE. Thus, although dependent on CD1 for their development, IL-4-secreting NK- like T cells are not required for T(H)2 responses.

Original languageEnglish (US)
Pages (from-to)977-979
Number of pages3
JournalScience
Volume275
Issue number5302
DOIs
StatePublished - Feb 14 1997

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