Immunohistochemical expression and localization of somatostatin receptors in normal prostate, high grade prostatic intraepithelial neoplasia and prostate cancer and its many faces

R. Mazzucchelli, M. Scarpelli, A. Lopez-Beltran, L. Cheng, R. Di Primio, A. Bono, Rodolfo Montironi

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Data on the immunohistochemical expression and localization of the five somatostatin receptors (SSTRs) have been obtained by our group in separate studies concerning the many faces of prostate cancer (PCa), its precursor high grade prostatic intraepithelial neoplasia (HGPIN) and normal epithelium (Nep). This publication highlights the key findings, with special reference to: normal prostate epithelium; untreated HGPIN and PCa, both clinically and incidentally detected; PCa with NE differentiation; HGPIN and PCa following complete androgen ablation (CAA); and hormone refractory (HR) PCa. Taken together, the data obtained in these investigations demonstrate that SSTR profiling in individual patients with HGPIN and the multifaceted PCa is feasible and is of relevance to better tailor the somatostatin analogue-based treatment.

Original languageEnglish (US)
Pages (from-to)181-192
Number of pages12
JournalJournal of biological regulators and homeostatic agents
Volume26
Issue number2
StatePublished - Apr 1 2012

Keywords

  • Complete androgen ablation
  • High-grade prostatic intraepithelial neoplasia
  • Hormone refractory prostate cancer
  • NE differentiation
  • Prostate
  • Prostate cancer
  • Somatostatin receptors

ASJC Scopus subject areas

  • Oncology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Immunology and Allergy
  • Immunology
  • Endocrinology
  • Physiology
  • Cancer Research

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