Immunohistochemical expression of prostate tumor overexpressed 1 in cystoprostatectomies with incidental and insignificant prostate cancer. Further evidence for field effect in prostatic carcinogenesis

Roberta Mazzucchelli, Francesca Barbisan, Alfredo Santinelli, Antonio Lopez-Beltran, Liang Cheng, Marina Scarpelli, Rodolfo Montironi

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Prostate tumor overexpressed 1 was recently identified as a novel gene and protein during a differential display screening for genes overexpressed in prostate cancer. It has been suggested that overexpression of prostate tumor overexpressed 1 can contribute to the proliferative status of prostate tumor cells and, thus, to their biologic behavior. Prostate tumor overexpressed 1 and Ki-67 were immunohistochemically evaluated in prostate cancer, high-grade prostatic intraepithelial neoplasia, and normal-looking epithelium in 20 cystoprostatectomies and 20 radical prostatectomies with pT2a Gleason score 6 prostate cancer. The aim was to see whether there were differences in marker expression between cystoprostatectomies and radical prostatectomies. The proportions of prostate tumor overexpressed 1- and Ki-67-positive cells in the cystoprostatectomies and radical prostatectomies increased from normal-looking epithelium through high-grade prostatic intraepithelial neoplasia, away from and adjacent to prostate cancer, to prostate cancer. Prostate tumor overexpressed 1 expression in prostate cancer in cystoprostatectomies was lower than in radical prostatectomies, the differences being significant; there were significant differences in Ki-67 indices. In conclusion, our findings related to prostate tumor overexpressed 1 expression in high-grade prostatic intraepithelial neoplasia, evaluated adjacent and away from prostate cancer, and in incidental and clinical cancers give further support to the concept of field effect in prostatic carcinogenesis as well as to differences in the process of prostatic carcinogenesis between cystoprostatectomies and radical prostatectomies.

Original languageEnglish (US)
Pages (from-to)1931-1936
Number of pages6
JournalHuman pathology
Volume42
Issue number12
DOIs
StatePublished - Dec 1 2011

Keywords

  • Cell proliferation
  • Cystoprostatectomy
  • High-grade prostatic intraepithelial neoplasia
  • Incidental cancer
  • Indolent cancer
  • Insignificant cancer
  • Ki-67
  • Prostate cancer
  • Prostate tumor overexpressed 1
  • Prostatic carcinogenesis
  • PTOV1
  • Significant cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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