Immunohistochemical expression of prostate tumour overexpressed 1 (PTOV1) in atypical adenomatous hyperplasia (AAH) of the prostate: Additional evidence linking AAH to adenocarcinoma

Roberta Mazzucchelli, Marina Scarpelli, Francesca Barbisan, Alfredo Santinelli, Antonio Lopez-Beltran, Liang Cheng, Rodolfo Montironi

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: Prostate tumour overexpressed 1, PTOV1, was recently identified as a novel gene and protein during a differential display screening for genes overexpressed in prostate cancer (PCa). It has been suggested that overexpression of PTOV1 can contribute to the proliferative status of prostate tumour cells and thus to their biological behaviour. Methods: PTOV1 and Ki67 were immunohistochemically evaluated in PCa, atypical adenomatous hyperplasia (AAH), high-grade prostatic intraepithelial neoplasia (HGPIN), and normal-looking epithelium (NEp) of the transition zone (TZ) in 40 radical prostatectomies with pT2a Gleason score 6 PCa (20 with AAH and 20 with HGPIN) and in 10 simple prostatectomies (SPs) (5 with AAH and 5 with HGPIN). The aim was to evaluate PTOV1 protein expression as a marker for tumor development and progression from AAH to PCa. Results: The proportions of PTOV1 and Ki67 positive cells increased from NEp through AAH and HGPIN to PCa. In particular, the mean Hscore of PTOV1 expression in AAH was 110.90, i.e., close to three times that of NEp (40.76), similar to that of HGPIN (105.61) and lower than that of PCa (137.03). The mean values in AAH and HGPIN associated with cancer in the RPs were slightly higher than in the SPs. Conclusion: Our findings related to PTOV1 expression in AAH, similar to those in HGPIN, provide additional evidence linking AAH to prostatic adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalCellular Oncology
Volume36
Issue number1
DOIs
StatePublished - Feb 1 2013

Keywords

  • Adenosis
  • Atypical adenomatous hyperplasia
  • Cell proliferation
  • High-grade prostatic intraepithelial neoplasia
  • Ki67
  • Prostate cancer
  • Prostate tumour overexpressed 1
  • PTOV1

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Oncology

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