Immunohistochemical markers in the evaluation of tumors of the urinary bladder

A review

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The clinical utility of immunohistochemistry in the diagnosis of tumors of the urinary bladder is well established. With recent advances in molecular biology and novel technologies, several biomarkers have emerged as important adjuncts in the diagnosis of lesions of the bladder. When used in conjunction with careful histologic examination, immunohistochemistry can be a valuable aid in classifying adenocarcinoma presenting in the bladder and mesenchymal lesions of the bladder and in establishing the urothelial origin of a metastatic tumor. In addition, a number of biomarkers may prove to be important indicators of prognosis or response to chemotherapy.

Original languageEnglish
Pages (from-to)301-316
Number of pages16
JournalAnalytical and Quantitative Cytology and Histology
Volume27
Issue number6
StatePublished - Dec 2005

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Urinary Bladder
Neoplasms
Biomarkers
Immunohistochemistry
Molecular Biology
Adenocarcinoma
Technology
Drug Therapy

Keywords

  • Biomarkers
  • Bladder neoplasms
  • Immunohistochemistry
  • Metastasis

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Cell Biology

Cite this

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abstract = "The clinical utility of immunohistochemistry in the diagnosis of tumors of the urinary bladder is well established. With recent advances in molecular biology and novel technologies, several biomarkers have emerged as important adjuncts in the diagnosis of lesions of the bladder. When used in conjunction with careful histologic examination, immunohistochemistry can be a valuable aid in classifying adenocarcinoma presenting in the bladder and mesenchymal lesions of the bladder and in establishing the urothelial origin of a metastatic tumor. In addition, a number of biomarkers may prove to be important indicators of prognosis or response to chemotherapy.",
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