Immunohistochemistry of central nervous system tumors. Its contribution to neurosurgical diagnosis

Jose Bonnin, L. J. Rubinstein

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Immunofluorescence and immunoperoxidase (peroxidase-antiperoxidase, PAP) techniques for the demonstration of neural and non-neural cell markers are contributing greatly to increase the diagnostic accuracy of difficult tumours of the central nervous system. Well characterized nervous system markers include glial fibrillary acidic (GFA) protein, the three proteins subunits of neurofilaments, neuron-specific enolase (NSE), myelin basic protein, and S-100 protein. The most important and reliable of these is GFA protein, which is widely in use for the immunohistochemical diagnosis of tumors of the glioma group. Its many practical applications are reviewed and illustrated. Other neural markers, in particular the specificity of NSE and S-100 protein, need to be critically evaluated. Problems related to the immunohistochemical diagnoses of central neuroepithelial tumors of putative neuroblastic origin remain complex and still need to be resolved. Non-neural markers, such as vimentin, desmin, cytokeratins, Factor VIII, alpha-fetoprotein, human chorionic gonadotropin, and immunoglobulins have well defined, although more restricted, applications in surgical neuropathy.

Original languageEnglish (US)
Pages (from-to)1121-1133
Number of pages13
JournalJournal of Neurosurgery
Volume60
Issue number6
StatePublished - 1984
Externally publishedYes

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Central Nervous System Neoplasms
S100 Proteins
Phosphopyruvate Hydratase
Glial Fibrillary Acidic Protein
Immunohistochemistry
Neuroepithelial Neoplasms
Desmin
Myelin Basic Protein
Intermediate Filaments
Protein S
Protein Subunits
Factor VIII
alpha-Fetoproteins
Vimentin
Chorionic Gonadotropin
Keratins
Glioma
Nervous System
Peroxidase
Fluorescent Antibody Technique

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Immunohistochemistry of central nervous system tumors. Its contribution to neurosurgical diagnosis. / Bonnin, Jose; Rubinstein, L. J.

In: Journal of Neurosurgery, Vol. 60, No. 6, 1984, p. 1121-1133.

Research output: Contribution to journalArticle

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