Immunological studies in tropical spastic paraparesis

Steven Jacobson, Ajay Gupta, David Mattson, Elizabeth Mingioli, Dale E. McFarlin

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Tropical spastic paraparesis (TSP) and other chronic-progressive myelopathies have been clearly associated with increased serum and cerebrospinal fluid antibody titers to human T-lymphotropic virus type I (HTLV-I). However, little is known about the cellular immune function in TSP. In the present study, activated T lymphocytes were found in the peripheral blood of patients with TSP. Specifically, there were increased numbers of large CD3+ cells that also expressed HLA-DR and interleukin-2-receptor molecules. A significantly elevated spontaneous lymphoproliferative response was demonstrated in all patients tested. Generation of measles virus-specific cytotoxic T-cell response was reduced in 4 of 4 patients. This was similar to previous findings in patients with multiple sclerosis. However, unlike multiple sclerosis, reduced generation of cytotoxic T-cell response to influenza and mumps viruses was observed in 2 of 4 patients. These observations confirm further the strong association between TSP and an HTLV-I-like virus and suggest that the observed abnormalities of the cellular immune response in TSP are related to infection of lymphocytes by the retrovirus.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalAnnals of Neurology
Volume27
Issue number2
StatePublished - Feb 1990
Externally publishedYes

Fingerprint

Tropical Spastic Paraparesis
Viruses
T-Lymphocytes
Multiple Sclerosis
Retroviridae Infections
Mumps virus
Measles virus
Interleukin-2 Receptors
Spinal Cord Diseases
HLA-DR Antigens
Orthomyxoviridae
Cellular Immunity
Cerebrospinal Fluid
Lymphocytes
Antibodies
Serum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jacobson, S., Gupta, A., Mattson, D., Mingioli, E., & McFarlin, D. E. (1990). Immunological studies in tropical spastic paraparesis. Annals of Neurology, 27(2), 149-156.

Immunological studies in tropical spastic paraparesis. / Jacobson, Steven; Gupta, Ajay; Mattson, David; Mingioli, Elizabeth; McFarlin, Dale E.

In: Annals of Neurology, Vol. 27, No. 2, 02.1990, p. 149-156.

Research output: Contribution to journalArticle

Jacobson, S, Gupta, A, Mattson, D, Mingioli, E & McFarlin, DE 1990, 'Immunological studies in tropical spastic paraparesis', Annals of Neurology, vol. 27, no. 2, pp. 149-156.
Jacobson S, Gupta A, Mattson D, Mingioli E, McFarlin DE. Immunological studies in tropical spastic paraparesis. Annals of Neurology. 1990 Feb;27(2):149-156.
Jacobson, Steven ; Gupta, Ajay ; Mattson, David ; Mingioli, Elizabeth ; McFarlin, Dale E. / Immunological studies in tropical spastic paraparesis. In: Annals of Neurology. 1990 ; Vol. 27, No. 2. pp. 149-156.
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