Immunoreactivity patterns in neurofibrillary tangles of the inferior temporal cortex in Alzheimer disease

Taihung Duong, Karen A. Gallagher

Research output: Contribution to journalArticle

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Abstract

The distributions of various immunohistochemical markers of neurofibrillary tangles (NFT) were compared to that of a normal nerve cell cytoskeletal marker, SMI32, in the inferior temporal cortex of Alzheimer brains and normal aged controls. NFT markers included antibodies to the microtubule-associated proteins tau, ubiquitin, or amyloid P component (AP). The results showed that, in our group of patients, the decrease of SMI32 immunoreactivity in the Alzheimer temporal cortex is paralleled by an increase in AP immunoreactivity in neurons and neurofibrillary tangles. This suggests that AP may play an important role in NFT formation or evolution in Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)105-122
Number of pages18
JournalMolecular and Chemical Neuropathology
Volume22
Issue number2
DOIs
StatePublished - Jun 1 1994

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Keywords

  • Amyloid P component
  • microtubule-associated proteins
  • neurofibrillary tangle
  • nonphosphorylated neurofilaments
  • tau
  • ubiquitin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Molecular Biology

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