Immunosuppressive effect of staphylococcus aureus peptidoglycan on antibody response in mice

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Abstract

Immunosuppressive effect of an adjuvant. Staphylococcus aureus peptidoglycan, on the primary IgM antibody response in mice was studied with application of the hemolytic plaque assay. Peptidoglycan suppressed the IgM response to thymus-dependent sheep erythrocyte antigen when given intravenously before immunization. The effect of peptidoglycan and erythrocytes was both time and dose dependent. For the suppression, both the delay in the antibody response and overall decreased response were responsible. Peptidoglycan did not influence background counts of antibody-forming cells. Priming with sub-threshold dose of erythrocytes did not overcome the suppression, although higher responses compared to unprimed animals were observed. Peptidoglycan did not suppress antibody response to thymus-independent antigens-lipopolysaccharidc or high dose of erythrocytes. It is suggested that peptidoglycan-induced immunosuppression is mediated by a presently unidentified population of helper cells-macrophages or T lymphocytes.

Original languageEnglish (US)
Pages (from-to)304-311
Number of pages8
JournalInternational Archives of Allergy and Immunology
Volume57
Issue number4
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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