Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders

Frauke Neff, Xing Wei, Carmen Nölker, Michael Bacher, Yansheng Du, Richard Dodel

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


Parkinson's disease, Alzheimer's disease and other neurodegenerative disorders share a common pathologic pathway with aggregation and deposition of misfolded proteins causing a disruption of particular neuronal networks. Several mechanisms have been implicated in the down-stream events following deposition of misfolded proteins including failure of cellular defenses among many others. Recently, naturally occurring autoantibodies against ß-amyloid and α-synuclein have been detected in healthy persons and altered levels in patients were associated with particular neurodegenerative disorders. In this review the current knowledge on the role of naturally occurring autoantibodies is discussed in respect to neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)501-507
Number of pages7
JournalAutoimmunity Reviews
Issue number6
StatePublished - Jun 1 2008


  • Alzheimer's disease
  • Creutzfeld-Jakob disease
  • Immunotherapy
  • Naturally occurring autoantibodies
  • Parkinson's disease

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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