Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders

Frauke Neff, Xing Wei, Carmen Nölker, Michael Bacher, Yansheng Du, Richard Dodel

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Parkinson's disease, Alzheimer's disease and other neurodegenerative disorders share a common pathologic pathway with aggregation and deposition of misfolded proteins causing a disruption of particular neuronal networks. Several mechanisms have been implicated in the down-stream events following deposition of misfolded proteins including failure of cellular defenses among many others. Recently, naturally occurring autoantibodies against ß-amyloid and α-synuclein have been detected in healthy persons and altered levels in patients were associated with particular neurodegenerative disorders. In this review the current knowledge on the role of naturally occurring autoantibodies is discussed in respect to neurodegenerative disorders.

Original languageEnglish
Pages (from-to)501-507
Number of pages7
JournalAutoimmunity Reviews
Volume7
Issue number6
DOIs
StatePublished - Jun 2008

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Neurodegenerative Diseases
Autoantibodies
Immunotherapy
Synucleins
Amyloid
Parkinson Disease
Alzheimer Disease
Proteins

Keywords

  • Alzheimer's disease
  • Creutzfeld-Jakob disease
  • Immunotherapy
  • Naturally occurring autoantibodies
  • Parkinson's disease

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders. / Neff, Frauke; Wei, Xing; Nölker, Carmen; Bacher, Michael; Du, Yansheng; Dodel, Richard.

In: Autoimmunity Reviews, Vol. 7, No. 6, 06.2008, p. 501-507.

Research output: Contribution to journalArticle

Neff, Frauke ; Wei, Xing ; Nölker, Carmen ; Bacher, Michael ; Du, Yansheng ; Dodel, Richard. / Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders. In: Autoimmunity Reviews. 2008 ; Vol. 7, No. 6. pp. 501-507.
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