Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans

Simran Banga, Jill D. Coursen, Silvia Portugal, Tuan M. Tran, Lisa Hancox, Aissata Ongoiba, Boubacar Traore, Ogobara K. Doumbo, Chiung Yu Huang, John T. Harty, Peter D. Crompton

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Vaccine-induced immunity depends on long-lived plasma cells (LLPCs) that maintain antibody levels. A recent mouse study showed that Plasmodium chaubaudi infection reduced pre-existing influenza-specific antibodies - raising concerns that malaria may compromise pre-existing vaccine responses. We extended these findings to P. yoelii infection, observing decreases in antibodies to model antigens in inbred mice and to influenza in outbred mice, associated with LLPC depletion and increased susceptibility to influenza rechallenge. We investigated the implications of these findings in Malian children by measuring vaccine-specific IgG (tetanus, measles, hepatitis B) before and after the malaria-free 6-month dry season, 10 days after the first malaria episode of the malaria season, and after the subsequent dry season. On average, vaccine-specific IgG did not decrease following acute malaria. However, in some children malaria was associated with an accelerated decline in vaccine-specific IgG, underscoring the need to further investigate the impact of malaria on pre-existing vaccine-specific antibodies.

Original languageEnglish (US)
Article numbere0125090
JournalPLoS One
Volume10
Issue number4
DOIs
StatePublished - Apr 28 2015
Externally publishedYes

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Viral Vaccines
Viral Antigens
malaria
Malaria
Vaccines
vaccines
antigens
Antigens
antibodies
Antibodies
mice
influenza
Human Influenza
Immunoglobulin G
plasma cells
Plasma Cells
dry season
Plasmas
tetanus
hepatitis B

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Banga, S., Coursen, J. D., Portugal, S., Tran, T. M., Hancox, L., Ongoiba, A., ... Crompton, P. D. (2015). Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans. PLoS One, 10(4), [e0125090]. https://doi.org/10.1371/journal.pone.0125090

Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans. / Banga, Simran; Coursen, Jill D.; Portugal, Silvia; Tran, Tuan M.; Hancox, Lisa; Ongoiba, Aissata; Traore, Boubacar; Doumbo, Ogobara K.; Huang, Chiung Yu; Harty, John T.; Crompton, Peter D.

In: PLoS One, Vol. 10, No. 4, e0125090, 28.04.2015.

Research output: Contribution to journalArticle

Banga, S, Coursen, JD, Portugal, S, Tran, TM, Hancox, L, Ongoiba, A, Traore, B, Doumbo, OK, Huang, CY, Harty, JT & Crompton, PD 2015, 'Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans', PLoS One, vol. 10, no. 4, e0125090. https://doi.org/10.1371/journal.pone.0125090
Banga, Simran ; Coursen, Jill D. ; Portugal, Silvia ; Tran, Tuan M. ; Hancox, Lisa ; Ongoiba, Aissata ; Traore, Boubacar ; Doumbo, Ogobara K. ; Huang, Chiung Yu ; Harty, John T. ; Crompton, Peter D. / Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans. In: PLoS One. 2015 ; Vol. 10, No. 4.
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