Impact of Antiretroviral Therapy on Lung Immunology and Inflammation

Homer Twigg, Kenneth S. Knox

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV) infection causes profound changes in the lung compartment characterized by macrophage and lymphocyte activation, secretion of proinflammatory cytokines and chemokines, and accumulation of CD8 T cells in the alveolar space, leading to lymphocytic alveolitis. Because many of the changes seen in the lung can be attributed to the direct effect of HIV on immune cells, therapy to reduce the HIV burden should have significant beneficial effects. Indeed, antiretroviral therapy rapidly reduces the viral burden in the lung, number of CD8 T cells in the alveolar space, and amount of proinflammatory cytokines and chemokines in bronchoalveolar lavage.

Original languageEnglish
Pages (from-to)155-164
Number of pages10
JournalClinics in Chest Medicine
Volume34
Issue number2
DOIs
StatePublished - Jun 2013

Fingerprint

Allergy and Immunology
Pneumonia
HIV
Chemokines
Lung
Cytokines
T-Lymphocytes
Macrophage Activation
Bronchoalveolar Lavage
Virus Diseases
Lymphocyte Activation
Cell- and Tissue-Based Therapy
Viral Load
Therapeutics

Keywords

  • Antiretroviral therapy (ART)
  • HIV
  • Pulmonary immune reconstitution

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Impact of Antiretroviral Therapy on Lung Immunology and Inflammation. / Twigg, Homer; Knox, Kenneth S.

In: Clinics in Chest Medicine, Vol. 34, No. 2, 06.2013, p. 155-164.

Research output: Contribution to journalArticle

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