Impact of chemotherapy and radiotherapy on the uterus

Abbie L. Fields, Deleep Kumar Gudipudi, Giuseppe Del Priore

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Survivorship issues surrounding conception and gestational outcome have gained recognition as the management and outcome of childhood malignancies has become increasingly successful. Issues surrounding future fertility are likely multifactorial including both direct and indirect effects of therapy on the pituitary system as well as the end organs. Radiation therapy impairs normal function of both the ovaries and the uterus. The magnitude of risk is related to the age and menarchal status at the time of treatment. Although all treatment for malignant disease is a balance between successful therapeutic outcome and minimized toxicity, it appears that the threshold for radiation is considerably lower than initially perceived. As cancer treatment and cures improve, assisted reproductive technology strives to keep pace. Oocyte cryopreservation, in vitro maturation, ovarian tissue cryopreservation, and uterus and ovary transplantation are all evolving to treat secondary infertility in cancer patients. Because of the rapidly changing field, it has become of paramount importance to educate both the parents and the patient with pediatric malignancy as to the impact their treatment may have on fertility and pregnancy outcome.

Original languageEnglish (US)
Title of host publicationFertility Preservation: Emerging Technologies and Clinical Applications
PublisherSpringer New York
Pages57-70
Number of pages14
ISBN (Print)9781441917836, 9781441917829
DOIs
StatePublished - Jan 1 2012

Fingerprint

Uterus
Radiotherapy
Drug Therapy
Cryopreservation
Fertility
Ovary
Neoplasms
Therapeutics
In Vitro Oocyte Maturation Techniques
Assisted Reproductive Techniques
Pregnancy Outcome
Infertility
Survival Rate
Transplantation
Parents
Radiation
Pediatrics

Keywords

  • Cancer and fertility
  • Cancer survivorship and fertility
  • Chemotherapy and fertility
  • Radiotherapy effects on the uterus
  • Uterus and chemotherapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fields, A. L., Gudipudi, D. K., & Del Priore, G. (2012). Impact of chemotherapy and radiotherapy on the uterus. In Fertility Preservation: Emerging Technologies and Clinical Applications (pp. 57-70). Springer New York. https://doi.org/10.1007/9781441917836_5

Impact of chemotherapy and radiotherapy on the uterus. / Fields, Abbie L.; Gudipudi, Deleep Kumar; Del Priore, Giuseppe.

Fertility Preservation: Emerging Technologies and Clinical Applications. Springer New York, 2012. p. 57-70.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fields, AL, Gudipudi, DK & Del Priore, G 2012, Impact of chemotherapy and radiotherapy on the uterus. in Fertility Preservation: Emerging Technologies and Clinical Applications. Springer New York, pp. 57-70. https://doi.org/10.1007/9781441917836_5
Fields AL, Gudipudi DK, Del Priore G. Impact of chemotherapy and radiotherapy on the uterus. In Fertility Preservation: Emerging Technologies and Clinical Applications. Springer New York. 2012. p. 57-70 https://doi.org/10.1007/9781441917836_5
Fields, Abbie L. ; Gudipudi, Deleep Kumar ; Del Priore, Giuseppe. / Impact of chemotherapy and radiotherapy on the uterus. Fertility Preservation: Emerging Technologies and Clinical Applications. Springer New York, 2012. pp. 57-70
@inbook{a1daaa2585ed4ed9b6d9ef7eda048dfe,
title = "Impact of chemotherapy and radiotherapy on the uterus",
abstract = "Survivorship issues surrounding conception and gestational outcome have gained recognition as the management and outcome of childhood malignancies has become increasingly successful. Issues surrounding future fertility are likely multifactorial including both direct and indirect effects of therapy on the pituitary system as well as the end organs. Radiation therapy impairs normal function of both the ovaries and the uterus. The magnitude of risk is related to the age and menarchal status at the time of treatment. Although all treatment for malignant disease is a balance between successful therapeutic outcome and minimized toxicity, it appears that the threshold for radiation is considerably lower than initially perceived. As cancer treatment and cures improve, assisted reproductive technology strives to keep pace. Oocyte cryopreservation, in vitro maturation, ovarian tissue cryopreservation, and uterus and ovary transplantation are all evolving to treat secondary infertility in cancer patients. Because of the rapidly changing field, it has become of paramount importance to educate both the parents and the patient with pediatric malignancy as to the impact their treatment may have on fertility and pregnancy outcome.",
keywords = "Cancer and fertility, Cancer survivorship and fertility, Chemotherapy and fertility, Radiotherapy effects on the uterus, Uterus and chemotherapy",
author = "Fields, {Abbie L.} and Gudipudi, {Deleep Kumar} and {Del Priore}, Giuseppe",
year = "2012",
month = "1",
day = "1",
doi = "10.1007/9781441917836_5",
language = "English (US)",
isbn = "9781441917836",
pages = "57--70",
booktitle = "Fertility Preservation: Emerging Technologies and Clinical Applications",
publisher = "Springer New York",

}

TY - CHAP

T1 - Impact of chemotherapy and radiotherapy on the uterus

AU - Fields, Abbie L.

AU - Gudipudi, Deleep Kumar

AU - Del Priore, Giuseppe

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Survivorship issues surrounding conception and gestational outcome have gained recognition as the management and outcome of childhood malignancies has become increasingly successful. Issues surrounding future fertility are likely multifactorial including both direct and indirect effects of therapy on the pituitary system as well as the end organs. Radiation therapy impairs normal function of both the ovaries and the uterus. The magnitude of risk is related to the age and menarchal status at the time of treatment. Although all treatment for malignant disease is a balance between successful therapeutic outcome and minimized toxicity, it appears that the threshold for radiation is considerably lower than initially perceived. As cancer treatment and cures improve, assisted reproductive technology strives to keep pace. Oocyte cryopreservation, in vitro maturation, ovarian tissue cryopreservation, and uterus and ovary transplantation are all evolving to treat secondary infertility in cancer patients. Because of the rapidly changing field, it has become of paramount importance to educate both the parents and the patient with pediatric malignancy as to the impact their treatment may have on fertility and pregnancy outcome.

AB - Survivorship issues surrounding conception and gestational outcome have gained recognition as the management and outcome of childhood malignancies has become increasingly successful. Issues surrounding future fertility are likely multifactorial including both direct and indirect effects of therapy on the pituitary system as well as the end organs. Radiation therapy impairs normal function of both the ovaries and the uterus. The magnitude of risk is related to the age and menarchal status at the time of treatment. Although all treatment for malignant disease is a balance between successful therapeutic outcome and minimized toxicity, it appears that the threshold for radiation is considerably lower than initially perceived. As cancer treatment and cures improve, assisted reproductive technology strives to keep pace. Oocyte cryopreservation, in vitro maturation, ovarian tissue cryopreservation, and uterus and ovary transplantation are all evolving to treat secondary infertility in cancer patients. Because of the rapidly changing field, it has become of paramount importance to educate both the parents and the patient with pediatric malignancy as to the impact their treatment may have on fertility and pregnancy outcome.

KW - Cancer and fertility

KW - Cancer survivorship and fertility

KW - Chemotherapy and fertility

KW - Radiotherapy effects on the uterus

KW - Uterus and chemotherapy

UR - http://www.scopus.com/inward/record.url?scp=84955164141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955164141&partnerID=8YFLogxK

U2 - 10.1007/9781441917836_5

DO - 10.1007/9781441917836_5

M3 - Chapter

AN - SCOPUS:84955164141

SN - 9781441917836

SN - 9781441917829

SP - 57

EP - 70

BT - Fertility Preservation: Emerging Technologies and Clinical Applications

PB - Springer New York

ER -