Abstract
Background: Endoscopic measures such as balloon dilation can relieve obstruction and improve symptoms in patients with primary sclerosing cholangitis (PSC). However, the influence of repeated endoscopy to maintain biliary patency on the survival of patients with PSC is unclear. Methods: This study evaluated the impact of endoscopic therapy on the survival of consecutive patients with PSC undergoing endoscopic therapy. During a 6-year period 63 patients underwent endoscopic therapy. After initial therapy, patients were followed for a median of 34 months. Endoscopic therapy primarily consisted of repeated balloon dilation of dominant biliary strictures. The observed survival of this cohort was estimated (Kaplan-Meier). The predicted survival of the cohort was estimated by using the Mayo Clinic survival model based on clinical information obtained within 3 months before first endoscopic therapy. The Mayo Risk Score was calculated by using the equation R = (0.03 Age, years) + (0.54 loge Bilirubin mg/dL) + (0.54 loge Aspartate aminotransferase U/mL) + (1.24 Bleed history) - (0.84 Albumin gm/dL). Results: The observed survival over 5 years was significantly higher than the predicted 5-year survival (83% vs. 65%, respectively; p = 0.027). Conclusion: These data suggest that repeated endoscopic attempts to maintain biliary patency may improve the survival of patients with PSC and dominant strictures.
| Original language | English |
|---|---|
| Pages (from-to) | 308-312 |
| Number of pages | 5 |
| Journal | Gastrointestinal Endoscopy |
| Volume | 53 |
| Issue number | 3 |
| State | Published - 2001 |
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ASJC Scopus subject areas
- Gastroenterology
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Impact of endoscopic therapy on the survival of patients with primary sclerosing cholangitis. / Baluyut, Arthur R.; Sherman, Stuart; Lehman, Glen; Hoen, Helena; Chalasani, Naga.
In: Gastrointestinal Endoscopy, Vol. 53, No. 3, 2001, p. 308-312.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of endoscopic therapy on the survival of patients with primary sclerosing cholangitis
AU - Baluyut, Arthur R.
AU - Sherman, Stuart
AU - Lehman, Glen
AU - Hoen, Helena
AU - Chalasani, Naga
PY - 2001
Y1 - 2001
N2 - Background: Endoscopic measures such as balloon dilation can relieve obstruction and improve symptoms in patients with primary sclerosing cholangitis (PSC). However, the influence of repeated endoscopy to maintain biliary patency on the survival of patients with PSC is unclear. Methods: This study evaluated the impact of endoscopic therapy on the survival of consecutive patients with PSC undergoing endoscopic therapy. During a 6-year period 63 patients underwent endoscopic therapy. After initial therapy, patients were followed for a median of 34 months. Endoscopic therapy primarily consisted of repeated balloon dilation of dominant biliary strictures. The observed survival of this cohort was estimated (Kaplan-Meier). The predicted survival of the cohort was estimated by using the Mayo Clinic survival model based on clinical information obtained within 3 months before first endoscopic therapy. The Mayo Risk Score was calculated by using the equation R = (0.03 Age, years) + (0.54 loge Bilirubin mg/dL) + (0.54 loge Aspartate aminotransferase U/mL) + (1.24 Bleed history) - (0.84 Albumin gm/dL). Results: The observed survival over 5 years was significantly higher than the predicted 5-year survival (83% vs. 65%, respectively; p = 0.027). Conclusion: These data suggest that repeated endoscopic attempts to maintain biliary patency may improve the survival of patients with PSC and dominant strictures.
AB - Background: Endoscopic measures such as balloon dilation can relieve obstruction and improve symptoms in patients with primary sclerosing cholangitis (PSC). However, the influence of repeated endoscopy to maintain biliary patency on the survival of patients with PSC is unclear. Methods: This study evaluated the impact of endoscopic therapy on the survival of consecutive patients with PSC undergoing endoscopic therapy. During a 6-year period 63 patients underwent endoscopic therapy. After initial therapy, patients were followed for a median of 34 months. Endoscopic therapy primarily consisted of repeated balloon dilation of dominant biliary strictures. The observed survival of this cohort was estimated (Kaplan-Meier). The predicted survival of the cohort was estimated by using the Mayo Clinic survival model based on clinical information obtained within 3 months before first endoscopic therapy. The Mayo Risk Score was calculated by using the equation R = (0.03 Age, years) + (0.54 loge Bilirubin mg/dL) + (0.54 loge Aspartate aminotransferase U/mL) + (1.24 Bleed history) - (0.84 Albumin gm/dL). Results: The observed survival over 5 years was significantly higher than the predicted 5-year survival (83% vs. 65%, respectively; p = 0.027). Conclusion: These data suggest that repeated endoscopic attempts to maintain biliary patency may improve the survival of patients with PSC and dominant strictures.
UR - http://www.scopus.com/inward/record.url?scp=0035092166&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035092166&partnerID=8YFLogxK
M3 - Article
C2 - 11231388
AN - SCOPUS:0035092166
VL - 53
SP - 308
EP - 312
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
SN - 0016-5107
IS - 3
ER -