Impact of hepatitis C virus infection on children and their caregivers

Quality of life, cognitive, and emotional outcomes

James R. Rodrigue, William Balistreri, Barbara Haber, Maureen M. Jonas, Parvathi Mohan, Jean Molleston, Karen F. Murray, Michael R. Narkewicz, Philip Rosenthal, Lesley J. Smith, Kathleen B. Schwarz, Patricia Robuck, Bruce Barton, Regino P. González-Peralta

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

OBJECTIVE: Hepatitis C virus (HCV) infection is associated with decreased quality of life (QOL) and neurocognitive dysfunction in adults, but little is known about its impact on children and their caregivers. PATIENTS AND METHODS: We studied the QOL, behavioral, emotional, and cognitive functioning of 114 treatment-naïve children with HCV enrolled in a placebo-controlled, randomized, multisite clinical trial evaluating peginterferon α-2a alone or with ribavirin. Baseline assessment included measures of children's QOL, cognitive functioning, behavioral adaptation, and depression. Caregivers' QOL also was assessed. RESULTS: Relative to published normative data, caregivers were more likely to believe that their children's health was poor and would likely worsen (t = 3.93; P < 0.0001), and reported higher concern about their children's health status (t = 6.63; P < 0.0001) and that this concern limited family activities (t = 2.45; P < 0.01); they also viewed their children as having more internalizing behavioral problems (t = 1.98; P < 0.05). Only 2 (2%) children had a score in the clinically depressed range. Children with HCV had worse cognitive functioning than the normative sample but significantly better functioning than children with attention-deficit/ hyperactivity disorder. Caregivers' QOL scores did not differ significantly from the normative sample, but infected mothers had lower QOL than noninfected caregivers. Caregivers were highly distressed about their children's medical circumstances. CONCLUSIONS: Although HCV infection, in its early stages, does not lead to global impairment in QOL, cognitive, behavioral, or emotional functioning in children, it is associated with higher caregiver stress and strain on the family system, and it may be associated with some cognitive changes in children.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume48
Issue number3
DOIs
StatePublished - Mar 2009

Fingerprint

Virus Diseases
Hepacivirus
Caregivers
Quality of Life
Ribavirin
Attention Deficit Disorder with Hyperactivity
Health Status
Randomized Controlled Trials
Placebos
Mothers
Depression

Keywords

  • Clinical trial
  • HCV
  • Parents
  • Quality of life

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Impact of hepatitis C virus infection on children and their caregivers : Quality of life, cognitive, and emotional outcomes. / Rodrigue, James R.; Balistreri, William; Haber, Barbara; Jonas, Maureen M.; Mohan, Parvathi; Molleston, Jean; Murray, Karen F.; Narkewicz, Michael R.; Rosenthal, Philip; Smith, Lesley J.; Schwarz, Kathleen B.; Robuck, Patricia; Barton, Bruce; González-Peralta, Regino P.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 48, No. 3, 03.2009, p. 341-347.

Research output: Contribution to journalArticle

Rodrigue, JR, Balistreri, W, Haber, B, Jonas, MM, Mohan, P, Molleston, J, Murray, KF, Narkewicz, MR, Rosenthal, P, Smith, LJ, Schwarz, KB, Robuck, P, Barton, B & González-Peralta, RP 2009, 'Impact of hepatitis C virus infection on children and their caregivers: Quality of life, cognitive, and emotional outcomes', Journal of Pediatric Gastroenterology and Nutrition, vol. 48, no. 3, pp. 341-347. https://doi.org/10.1097/MPG.0b013e318185998f
Rodrigue, James R. ; Balistreri, William ; Haber, Barbara ; Jonas, Maureen M. ; Mohan, Parvathi ; Molleston, Jean ; Murray, Karen F. ; Narkewicz, Michael R. ; Rosenthal, Philip ; Smith, Lesley J. ; Schwarz, Kathleen B. ; Robuck, Patricia ; Barton, Bruce ; González-Peralta, Regino P. / Impact of hepatitis C virus infection on children and their caregivers : Quality of life, cognitive, and emotional outcomes. In: Journal of Pediatric Gastroenterology and Nutrition. 2009 ; Vol. 48, No. 3. pp. 341-347.
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