Impact of obesity and body fat distribution on survival after pancreaticoduodenectomy for pancreatic adenocarcinoma

Sébastien Gaujoux, Javiera Torres, Sara Olson, Corrine Winston, Mithat Gonen, Murray F. Brennan, David S. Klimstra, Michael D'Angelica, Ronald Dematteo, Yuman Fong, Michael House, William Jarnagin, Robert C. Kurtz, Peter J. Allen

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Background: Epidemiologic studies have reported a positive correlation between body mass index (BMI) and pancreatic cancer risk, but clinical relevance of obesity and/or body fat distribution on tumor characteristics and cancer-related outcome remain controversial. We sought to assess the influence of obesity and body fat distribution on pathologic characteristics and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Methods: Demographic and biometric data were collected on 328 patients undergoing pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. In a subset of patients, pancreatic fatty infiltration and fibrosis were assessed pathologically, and visceral fat area (VFA) was evaluated. Influence of BMI and body fat distribution on tumor characteristics and survival were evaluated. Results: A significant positive correlation between BMI and VFA was observed, with a wide range of VFA value within each BMI class. According to BMI or VFA distribution, there were no significant differences in patient characteristics, intraoperative or perioperative outcome, or pathologic characteristics, with the exception of significantly higher blood loss in patients with an increased body weight or VFA. Unadjusted overall and disease-free survival between BMI class and VFA quartile were not significantly different. Conclusions: In this study, obesity and body fat distribution were not correlated with specific tumor characteristics or cancer-related outcome.

Original languageEnglish (US)
Pages (from-to)2908-2916
Number of pages9
JournalAnnals of Surgical Oncology
Volume19
Issue number9
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Gaujoux, S., Torres, J., Olson, S., Winston, C., Gonen, M., Brennan, M. F., Klimstra, D. S., D'Angelica, M., Dematteo, R., Fong, Y., House, M., Jarnagin, W., Kurtz, R. C., & Allen, P. J. (2012). Impact of obesity and body fat distribution on survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Annals of Surgical Oncology, 19(9), 2908-2916. https://doi.org/10.1245/s10434-012-2301-y