Impact of recipient age on whole organ pancreas transplantation

Ashesh P. Shah, Richard Mangus, John A. Powelson, Kannan P. Samy, Tim Taber, Michelle L. Goble, Jonathan A. Fridell

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aim: The goal of this study was to assess the impact of recipient age on post-transplant outcome. Methods: All pancreas transplants performed at Indiana University between 2003 and 2011 were reviewed. Demographic data were compared using standard chi-square and ANOVA testing. Standard Cox regression survival analysis was performed using a direct entry method for covariates. Results: Patients (n = 405) were divided by decade: <30 yr (n = 37), 30-39 (n = 109), 40-49 (n = 156), 50-59 (n = 85), and ≥60 yr of age (n = 18). Group demographics did not differ except for median ischemia time, which was between 7.0 and 8.5 h (p = 0.02). Early graft loss and one yr graft and patient survival were similar between the groups. Long-term patient survival demonstrated a trend toward decreased five-yr survival with increasing recipient age (p = NS). Graft survival at five yr by Cox regression was the lowest for the <30 yr group (74%), while all other groups were similar around 80% (p = NS). Conclusion: No statistically significant differences in pancreas transplant outcomes were demonstrated when recipients were stratified by recipient age. These results suggest that older recipients can successfully undergo pancreas transplantation and expect five-yr outcomes similar to those seen in younger recipients.

Original languageEnglish
JournalClinical Transplantation
Volume27
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Pancreas Transplantation
Organ Transplantation
Transplants
Graft Survival
Pancreas
Demography
Survival
Survival Analysis
Analysis of Variance
Ischemia
Regression Analysis

Keywords

  • Age
  • Outcomes
  • Pancreas transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Impact of recipient age on whole organ pancreas transplantation. / Shah, Ashesh P.; Mangus, Richard; Powelson, John A.; Samy, Kannan P.; Taber, Tim; Goble, Michelle L.; Fridell, Jonathan A.

In: Clinical Transplantation, Vol. 27, No. 1, 01.2013.

Research output: Contribution to journalArticle

Shah, Ashesh P. ; Mangus, Richard ; Powelson, John A. ; Samy, Kannan P. ; Taber, Tim ; Goble, Michelle L. ; Fridell, Jonathan A. / Impact of recipient age on whole organ pancreas transplantation. In: Clinical Transplantation. 2013 ; Vol. 27, No. 1.
@article{010179d7593248129ca97ecff8b57ba4,
title = "Impact of recipient age on whole organ pancreas transplantation",
abstract = "Aim: The goal of this study was to assess the impact of recipient age on post-transplant outcome. Methods: All pancreas transplants performed at Indiana University between 2003 and 2011 were reviewed. Demographic data were compared using standard chi-square and ANOVA testing. Standard Cox regression survival analysis was performed using a direct entry method for covariates. Results: Patients (n = 405) were divided by decade: <30 yr (n = 37), 30-39 (n = 109), 40-49 (n = 156), 50-59 (n = 85), and ≥60 yr of age (n = 18). Group demographics did not differ except for median ischemia time, which was between 7.0 and 8.5 h (p = 0.02). Early graft loss and one yr graft and patient survival were similar between the groups. Long-term patient survival demonstrated a trend toward decreased five-yr survival with increasing recipient age (p = NS). Graft survival at five yr by Cox regression was the lowest for the <30 yr group (74{\%}), while all other groups were similar around 80{\%} (p = NS). Conclusion: No statistically significant differences in pancreas transplant outcomes were demonstrated when recipients were stratified by recipient age. These results suggest that older recipients can successfully undergo pancreas transplantation and expect five-yr outcomes similar to those seen in younger recipients.",
keywords = "Age, Outcomes, Pancreas transplantation",
author = "Shah, {Ashesh P.} and Richard Mangus and Powelson, {John A.} and Samy, {Kannan P.} and Tim Taber and Goble, {Michelle L.} and Fridell, {Jonathan A.}",
year = "2013",
month = "1",
doi = "10.1111/ctr.12047",
language = "English",
volume = "27",
journal = "Clinical Transplantation",
issn = "0902-0063",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Impact of recipient age on whole organ pancreas transplantation

AU - Shah, Ashesh P.

AU - Mangus, Richard

AU - Powelson, John A.

AU - Samy, Kannan P.

AU - Taber, Tim

AU - Goble, Michelle L.

AU - Fridell, Jonathan A.

PY - 2013/1

Y1 - 2013/1

N2 - Aim: The goal of this study was to assess the impact of recipient age on post-transplant outcome. Methods: All pancreas transplants performed at Indiana University between 2003 and 2011 were reviewed. Demographic data were compared using standard chi-square and ANOVA testing. Standard Cox regression survival analysis was performed using a direct entry method for covariates. Results: Patients (n = 405) were divided by decade: <30 yr (n = 37), 30-39 (n = 109), 40-49 (n = 156), 50-59 (n = 85), and ≥60 yr of age (n = 18). Group demographics did not differ except for median ischemia time, which was between 7.0 and 8.5 h (p = 0.02). Early graft loss and one yr graft and patient survival were similar between the groups. Long-term patient survival demonstrated a trend toward decreased five-yr survival with increasing recipient age (p = NS). Graft survival at five yr by Cox regression was the lowest for the <30 yr group (74%), while all other groups were similar around 80% (p = NS). Conclusion: No statistically significant differences in pancreas transplant outcomes were demonstrated when recipients were stratified by recipient age. These results suggest that older recipients can successfully undergo pancreas transplantation and expect five-yr outcomes similar to those seen in younger recipients.

AB - Aim: The goal of this study was to assess the impact of recipient age on post-transplant outcome. Methods: All pancreas transplants performed at Indiana University between 2003 and 2011 were reviewed. Demographic data were compared using standard chi-square and ANOVA testing. Standard Cox regression survival analysis was performed using a direct entry method for covariates. Results: Patients (n = 405) were divided by decade: <30 yr (n = 37), 30-39 (n = 109), 40-49 (n = 156), 50-59 (n = 85), and ≥60 yr of age (n = 18). Group demographics did not differ except for median ischemia time, which was between 7.0 and 8.5 h (p = 0.02). Early graft loss and one yr graft and patient survival were similar between the groups. Long-term patient survival demonstrated a trend toward decreased five-yr survival with increasing recipient age (p = NS). Graft survival at five yr by Cox regression was the lowest for the <30 yr group (74%), while all other groups were similar around 80% (p = NS). Conclusion: No statistically significant differences in pancreas transplant outcomes were demonstrated when recipients were stratified by recipient age. These results suggest that older recipients can successfully undergo pancreas transplantation and expect five-yr outcomes similar to those seen in younger recipients.

KW - Age

KW - Outcomes

KW - Pancreas transplantation

UR - http://www.scopus.com/inward/record.url?scp=84873078191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873078191&partnerID=8YFLogxK

U2 - 10.1111/ctr.12047

DO - 10.1111/ctr.12047

M3 - Article

C2 - 23228216

AN - SCOPUS:84873078191

VL - 27

JO - Clinical Transplantation

JF - Clinical Transplantation

SN - 0902-0063

IS - 1

ER -