Impact of recipient age on whole organ pancreas transplantation

Ashesh P. Shah, Richard S. Mangus, John A. Powelson, Kannan P. Samy, Tim E. Taber, Michelle L. Goble, Jonathan A. Fridell

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aim: The goal of this study was to assess the impact of recipient age on post-transplant outcome. Methods: All pancreas transplants performed at Indiana University between 2003 and 2011 were reviewed. Demographic data were compared using standard chi-square and ANOVA testing. Standard Cox regression survival analysis was performed using a direct entry method for covariates. Results: Patients (n = 405) were divided by decade: <30 yr (n = 37), 30-39 (n = 109), 40-49 (n = 156), 50-59 (n = 85), and ≥60 yr of age (n = 18). Group demographics did not differ except for median ischemia time, which was between 7.0 and 8.5 h (p = 0.02). Early graft loss and one yr graft and patient survival were similar between the groups. Long-term patient survival demonstrated a trend toward decreased five-yr survival with increasing recipient age (p = NS). Graft survival at five yr by Cox regression was the lowest for the <30 yr group (74%), while all other groups were similar around 80% (p = NS). Conclusion: No statistically significant differences in pancreas transplant outcomes were demonstrated when recipients were stratified by recipient age. These results suggest that older recipients can successfully undergo pancreas transplantation and expect five-yr outcomes similar to those seen in younger recipients.

Original languageEnglish (US)
Pages (from-to)E49-E55
JournalClinical Transplantation
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Pancreas Transplantation
Organ Transplantation
Transplants
Graft Survival
Pancreas
Demography
Survival
Survival Analysis
Analysis of Variance
Ischemia
Regression Analysis

Keywords

  • Age
  • Outcomes
  • Pancreas transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Shah, A. P., Mangus, R. S., Powelson, J. A., Samy, K. P., Taber, T. E., Goble, M. L., & Fridell, J. A. (2013). Impact of recipient age on whole organ pancreas transplantation. Clinical Transplantation, 27(1), E49-E55. https://doi.org/10.1111/ctr.12047

Impact of recipient age on whole organ pancreas transplantation. / Shah, Ashesh P.; Mangus, Richard S.; Powelson, John A.; Samy, Kannan P.; Taber, Tim E.; Goble, Michelle L.; Fridell, Jonathan A.

In: Clinical Transplantation, Vol. 27, No. 1, 01.01.2013, p. E49-E55.

Research output: Contribution to journalArticle

Shah, AP, Mangus, RS, Powelson, JA, Samy, KP, Taber, TE, Goble, ML & Fridell, JA 2013, 'Impact of recipient age on whole organ pancreas transplantation', Clinical Transplantation, vol. 27, no. 1, pp. E49-E55. https://doi.org/10.1111/ctr.12047
Shah, Ashesh P. ; Mangus, Richard S. ; Powelson, John A. ; Samy, Kannan P. ; Taber, Tim E. ; Goble, Michelle L. ; Fridell, Jonathan A. / Impact of recipient age on whole organ pancreas transplantation. In: Clinical Transplantation. 2013 ; Vol. 27, No. 1. pp. E49-E55.
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