Impact of target volume coverage with Radiation Therapy Oncology Group (RTOG) 98-05 guidelines for transrectal ultrasound guided permanent Iodine-125 prostate implants

Eric M. Horwitz, Raj K. Mitra, Robert G. Uzzo, Indra J. Das, Wayne H. Pinover, Alexandra L. Hanlon, Shawn W. McNeeley, Gerald E. Hanks

Research output: Contribution to journalArticle

14 Scopus citations


Purpose: Despite the wide use of permanent prostate implants for the treatment of early stage prostate cancer, there is no consensus for optimal pre-implant planning guidelines that results in maximal post-implant target coverage. The purpose of this study was to compare post-implant target volume coverage and dosimetry between patients treated before and after Radiation Therapy Oncology Group (RTOG) 98-05 guidelines were adopted using several dosimetric endpoints. Materials and methods: Ten consecutively treated patients before the adoption of the RTOG 98-05 planning guidelines were compared with ten consecutively treated patients after implementation of the guidelines. Pre-implant planning for patients treated pre-RTOG was based on the clinical target volume (CTV) defined by the pre-implant TRUS definition of the prostate. The CTV was expanded in each dimension according to RTOG 98-05 and defined as the planning target volume. The evaluation target volume was defined as the post-implant computed tomography definition of the prostate based on RTOG 98-05 protocol recommendations. Implant quality indicators included V100, V90, V100, and Coverage Index (CI). Results: The pre-RTOG median V100, V90, D90, and CI values were 82.8, 88.9%, 126.5 Gy, and 17.1, respectively. The median post-RTOG V100, V90, D90, and CI values were 96.0, 97.8%, 169.2 Gy, and 4.0, respectively. These differences were all statistically significant. Conclusions: Implementation of the RTOG 98-05 implant planning guidelines has increased coverage of the prostate by the prescription isodose lines compared with our previous technique, as indicated by post-implant dosimetry indices such as V100, V90, D90. The CI was also improved significantly with the protocol guidelines. Our data confirms the validity of the RTOG 98-05 implant guidelines for pre-implant planning as it relates to enlargement of the CTV to ensure adequate margin between the CTV and the prescription isodose lines.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalRadiotherapy and Oncology
Issue number2
StatePublished - Feb 1 2003



  • Brachytherapy
  • Dosimetry
  • Iodine-125
  • Permanent prostate implant
  • Prostatic neoplasms
  • Radiation Therapy Oncology Group

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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