Impaired alveolar macrophage accessory cell function and reduced incidence of lymphocytic alveolitis in HIV-infected patients who smoke

Homer Twigg, Diaa M. Soliman, Blake A. Spain

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: To determine the effects of smoking on alveolar macrophage (AM) accessory cell (AC) function and the incidence of lymphocytic alveolitis in asymptomatic HIV-infected individuals. Methods: AM AC function in smoking and nonsmoking HIV-positive volunteers was measured in concanavalin A and pokeweed mitogen assays. Mitogen-induced AM-T-cell adherence was determined. AM cytokine secretion was analyzed by interleukin (IL)-6 bioassay and IL-1 enzyme-linked immunosorbent assay (ELISA). The incidence of lymphocytic alveolitis in both groups was determined. Results: AM from smokers were significantly poorer AC than AM from nonsmokers. Though AM-T-cell adherence was unaffected by smoking, IL-1 and IL-6 secretion was significantly impaired. Lymphocytic alveolitis was significantly less common in HIV-infected smokers. Conclusion: Smoking reduces AM AC function in HIV-infected individuals, probably by impairing secretion of cytokines important in T-cell proliferation. This may explain the decreased incidence of lymphocytic alveolitis in HIV-infected people who smoke.

Original languageEnglish
Pages (from-to)611-618
Number of pages8
JournalAIDS
Volume8
Issue number5
StatePublished - May 1994

Fingerprint

Alveolar Macrophages
Smoke
HIV
Incidence
Smoking
T-Lymphocytes
Interleukin-1
Interleukin-6
Cytokines
Pokeweed Mitogens
Concanavalin A
Mitogens
Biological Assay
Volunteers
Enzyme-Linked Immunosorbent Assay
Cell Proliferation

Keywords

  • Accessory cell
  • Alveolar macrophage
  • Alveolar macrophage-T-cell adherence
  • HIV infection
  • Interleukin-1
  • Interleukin-6
  • Lymphocytic alveolitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Impaired alveolar macrophage accessory cell function and reduced incidence of lymphocytic alveolitis in HIV-infected patients who smoke. / Twigg, Homer; Soliman, Diaa M.; Spain, Blake A.

In: AIDS, Vol. 8, No. 5, 05.1994, p. 611-618.

Research output: Contribution to journalArticle

@article{8cc309e6a17b4b1592f00085d4fdc269,
title = "Impaired alveolar macrophage accessory cell function and reduced incidence of lymphocytic alveolitis in HIV-infected patients who smoke",
abstract = "Objective: To determine the effects of smoking on alveolar macrophage (AM) accessory cell (AC) function and the incidence of lymphocytic alveolitis in asymptomatic HIV-infected individuals. Methods: AM AC function in smoking and nonsmoking HIV-positive volunteers was measured in concanavalin A and pokeweed mitogen assays. Mitogen-induced AM-T-cell adherence was determined. AM cytokine secretion was analyzed by interleukin (IL)-6 bioassay and IL-1 enzyme-linked immunosorbent assay (ELISA). The incidence of lymphocytic alveolitis in both groups was determined. Results: AM from smokers were significantly poorer AC than AM from nonsmokers. Though AM-T-cell adherence was unaffected by smoking, IL-1 and IL-6 secretion was significantly impaired. Lymphocytic alveolitis was significantly less common in HIV-infected smokers. Conclusion: Smoking reduces AM AC function in HIV-infected individuals, probably by impairing secretion of cytokines important in T-cell proliferation. This may explain the decreased incidence of lymphocytic alveolitis in HIV-infected people who smoke.",
keywords = "Accessory cell, Alveolar macrophage, Alveolar macrophage-T-cell adherence, HIV infection, Interleukin-1, Interleukin-6, Lymphocytic alveolitis",
author = "Homer Twigg and Soliman, {Diaa M.} and Spain, {Blake A.}",
year = "1994",
month = "5",
language = "English",
volume = "8",
pages = "611--618",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Impaired alveolar macrophage accessory cell function and reduced incidence of lymphocytic alveolitis in HIV-infected patients who smoke

AU - Twigg, Homer

AU - Soliman, Diaa M.

AU - Spain, Blake A.

PY - 1994/5

Y1 - 1994/5

N2 - Objective: To determine the effects of smoking on alveolar macrophage (AM) accessory cell (AC) function and the incidence of lymphocytic alveolitis in asymptomatic HIV-infected individuals. Methods: AM AC function in smoking and nonsmoking HIV-positive volunteers was measured in concanavalin A and pokeweed mitogen assays. Mitogen-induced AM-T-cell adherence was determined. AM cytokine secretion was analyzed by interleukin (IL)-6 bioassay and IL-1 enzyme-linked immunosorbent assay (ELISA). The incidence of lymphocytic alveolitis in both groups was determined. Results: AM from smokers were significantly poorer AC than AM from nonsmokers. Though AM-T-cell adherence was unaffected by smoking, IL-1 and IL-6 secretion was significantly impaired. Lymphocytic alveolitis was significantly less common in HIV-infected smokers. Conclusion: Smoking reduces AM AC function in HIV-infected individuals, probably by impairing secretion of cytokines important in T-cell proliferation. This may explain the decreased incidence of lymphocytic alveolitis in HIV-infected people who smoke.

AB - Objective: To determine the effects of smoking on alveolar macrophage (AM) accessory cell (AC) function and the incidence of lymphocytic alveolitis in asymptomatic HIV-infected individuals. Methods: AM AC function in smoking and nonsmoking HIV-positive volunteers was measured in concanavalin A and pokeweed mitogen assays. Mitogen-induced AM-T-cell adherence was determined. AM cytokine secretion was analyzed by interleukin (IL)-6 bioassay and IL-1 enzyme-linked immunosorbent assay (ELISA). The incidence of lymphocytic alveolitis in both groups was determined. Results: AM from smokers were significantly poorer AC than AM from nonsmokers. Though AM-T-cell adherence was unaffected by smoking, IL-1 and IL-6 secretion was significantly impaired. Lymphocytic alveolitis was significantly less common in HIV-infected smokers. Conclusion: Smoking reduces AM AC function in HIV-infected individuals, probably by impairing secretion of cytokines important in T-cell proliferation. This may explain the decreased incidence of lymphocytic alveolitis in HIV-infected people who smoke.

KW - Accessory cell

KW - Alveolar macrophage

KW - Alveolar macrophage-T-cell adherence

KW - HIV infection

KW - Interleukin-1

KW - Interleukin-6

KW - Lymphocytic alveolitis

UR - http://www.scopus.com/inward/record.url?scp=0028296096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028296096&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 611

EP - 618

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 5

ER -