Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke

Walter N. Kernan, S. E. Inzucchi, C. M. Viscoli, L. M. Brass, Dawn Bravata, G. I. Shulman, J. C. McVeety, R. I. Horwitz

Research output: Contribution to journalArticle

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Abstract

Objectives: To determine the prevalence of impaired insulin sensitivity among nondiabetic patients with a recent TIA or nondisabling ischemic stroke. Methods: Eligible subjects were nondiabetic men and women over age 45 years who were hospitalized with a TIA or ischemic stroke. To measure insulin sensitivity, subjects underwent an oral glucose tolerance test between 2 and 6 months after their event. Impaired insulin sensitivity was defined by a value of ≤2.5 on the Composite Insulin Sensitivity Index derived from insulin and glucose values during the test. Results: Between July 2000 and June 2001, we identified 177 eligible patients, among whom 105 declined to participate and 72 enrolled. The median age of participants was 71 years and 46 (64%) were men. The baseline event was stroke for 57 subjects (79%). A history of myocardial infarction (MI) was reported by 14 subjects (19%), and 16 (22%) were obese (body mass index > 30). Fasting glucose was normal (1). Conclusion: Impaired insulin sensitivity is highly prevalent among nondiabetic patients with a recent TIA or nondisabling ischemic stroke. This finding has important therapeutic implications if treatment to improve insulin sensitivity is shown to reduce risk for subsequent stroke and heart disease.

Original languageEnglish (US)
Pages (from-to)1447-1451
Number of pages5
JournalNeurology
Volume60
Issue number9
StatePublished - May 13 2003
Externally publishedYes

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Insulin Resistance
Stroke
Glucose
Glucose Tolerance Test
Heart Diseases
Fasting
Body Mass Index
Myocardial Infarction
Insulin
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kernan, W. N., Inzucchi, S. E., Viscoli, C. M., Brass, L. M., Bravata, D., Shulman, G. I., ... Horwitz, R. I. (2003). Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke. Neurology, 60(9), 1447-1451.

Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke. / Kernan, Walter N.; Inzucchi, S. E.; Viscoli, C. M.; Brass, L. M.; Bravata, Dawn; Shulman, G. I.; McVeety, J. C.; Horwitz, R. I.

In: Neurology, Vol. 60, No. 9, 13.05.2003, p. 1447-1451.

Research output: Contribution to journalArticle

Kernan, WN, Inzucchi, SE, Viscoli, CM, Brass, LM, Bravata, D, Shulman, GI, McVeety, JC & Horwitz, RI 2003, 'Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke', Neurology, vol. 60, no. 9, pp. 1447-1451.
Kernan WN, Inzucchi SE, Viscoli CM, Brass LM, Bravata D, Shulman GI et al. Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke. Neurology. 2003 May 13;60(9):1447-1451.
Kernan, Walter N. ; Inzucchi, S. E. ; Viscoli, C. M. ; Brass, L. M. ; Bravata, Dawn ; Shulman, G. I. ; McVeety, J. C. ; Horwitz, R. I. / Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke. In: Neurology. 2003 ; Vol. 60, No. 9. pp. 1447-1451.
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